Porphyrinoid Photosensitizers for Targeted and Precise Photodynamic Therapy: Progress in Fabrication

Abstract

This chapter focuses on basic facts and details of photodynamic therapy (PDT). PDT’s ability to cause cytotoxicity has led to its applications for a variety of medical conditions other than cancer treatment. This adaptable technology has some advantages in treating severe illness situations such as cancer, alopecia, angina pectoris, and periodontitis. It stands out even more because of the interaction of three elements: light, a photosensitizer (PS), and cellular oxygen. By preventing PS accumulation in normal vegetative cells, targeted photodynamic therapy plays an important role in achieving better accumulation of PS in a specific area. This section discusses various types of targeting methods, such as active targeting, passive targeting, and peptide-mediated targeting. Aid in both diagnosing and curing diseases, gaining widespread acceptance. It is a promising therapeutic approach with a lot of potential.

A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer

“…The most used targeting ligands are FA and TF, included in photodynamic therapy (PDT). While the targeted delivery of photosensitizers (PSs) is more often investigated in nanocarriers, the production of bioconjugates with enhanced selectivity for cancer cells is described by investigators . Although improved internalization by cancer cells is lacking studies, this work for the manufacture of new FA-targeted PS conjugates can serve as a guideline .…”

“…While the targeted delivery of photosensitizers (PSs) is more often investigated in nanocarriers, the production of bioconjugates with enhanced selectivity for cancer cells is described by investigators. 105 Although improved internalization by cancer cells is lacking studies, this work for the manufacture of new FA-targeted PS conjugates can serve as a guideline. 106 Platinum porphyrin and FA form a complex from carboxylic acid activation, permitting its amide bond formation with the linker and yielding a novel FA-targeted PS selective for FRα-positive cell lines.…”