Porphyrias and Porphyrin Metabolism, with Special Reference to Porphyria in Childhood

DOĞRAMACI, İDHSAN

doi:10.1016/s0065-3101(22)00490-x

Cited by 29 publications

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Carcinogenesis of hexachlorobenzene in mice

Cabral¹,

Mollner²,

Raitano³

et al. 1979

Intl Journal of Cancer

View full text Add to dashboard Cite

Hexachlorobenzene (HCB) is a fungicide and a by-product i n the manufacture o f many chlorinated solvents and pesticides. I n Turkey, between 1955 and 1959 HCB was the causative agent of an epidemic of toxic porphyria, which involved more than 3,000 people, predominantly children. HCB was studied i n long-term experiments for carcinogenicity i n mice. Outbred Swiss mice were given H C B i n the diet a t dose levels of 50, I00 and 200 parts per million (ppm), for 101-120 weeks. Survival rates i n females and males of group HCB 200 were markedly affected by deaths due t o toxic manifestations of HCB. All survivors were killed at 120 weeks. Exposure t o HCB resulted i n an increased incidence of liver-cell tumors in groups HCB 100 and HCB 200. N o livercell tumors were observed in the controls and in the group fed H C B 50. The incidence of mouse lymphomas was 35% i n controls and 11% i n H C B ZOO. The decrease reflects probably the shortest life-span of HCB-treated animals. The incidence of lung tumors was higher in controls than in the treated groups, but the multiplicity (nodule/mouse) was approximately the same in all groups. I n a separate experiment 30 female and 30 male mice were administered 300 ppm HCB i n the diet for only 15 weeks. Most of the males died early. The survival rate a t 110 weeks of age was 10% and comparable t o that of controls. Two mice in the HCB 300 group developed liver-cell tumors.The proportion of tumor-bearing animals and the incidence of lymphomas, lung adenomas and other tumor types i n HCB 300 mice were similar t o those reported in control animals. The present results indicate the carcinogenicity effect of H C B in mice.

show abstract