Porphobilinogen as a Porphyrin Precursor, and Interconversion of Porphyrins, in a Tissue System

Falk, J. E.; Dresel, E. I. B.; Rimington, C.

doi:10.1038/172292a0

Cited by 115 publications

(28 citation statements)

References 10 publications

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“…Apart from constipation, there is no evidence that the state of these rabbits compared with the clinical state of human acute porphyria, although the animals excreted proportionately greater quantities of the substances. Falk, Dresel, and Rimington (1953) have shown that porphobilinogen is a porphyrin precursor in a tissue system. This emphasizes that in porphobilinogen we are probably dealing with a physiological substance.…”

Section: Discussionmentioning

confidence: 99%

Pharmacology of the Porphyrins and Porphobilinogen

Goldberg

Patón

Thompson

1954

British Journal of Pharmacology and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Pharmacology of the Porphyrins and Porphobilinogen

Goldberg

Patón

Thompson

1954

British Journal of Pharmacology and Chemotherapy

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“…As a result of the efforts of a number of investigators, whose work is summarized in Figure 1, a pathway for the biosynthesis of heme has been outlined (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

mentioning

confidence: 99%

In Vitro Pyrrole and Porphyrin Synthesis in Lead Poisoning and Iron Deficiency*

Lichtman¹,

Feldman²

1963

J. Clin. Invest.

116

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“…This enzyme is located in the soluble cytoplasm of the cell. ALA-D was first found in chick erythrocytes by Falk et al (5). Thereafter, the activity of this enzyme was recognized in many other tissues.…”

Section: Discussionmentioning

confidence: 97%

Analyses of δ‐Aminolevulinic Acid Dehydratase Activity and Protoporphyrin Levels in Erythrocytes among Three Different Species

Murayama¹,

Nonaka

Ohgami

et al. 1986

The Journal of Dermatology

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Delta-aminolevulinic acid dehydratase (ALA-D) is a enzyme that participates in the pathway from 15-aminolevulinic acid (ALA) to porphobilinogen (PBG). This enzyme is relatively easy to analyze because erythrocytes can be utilized as the sample. However, it is not completely understood what kinds of abnormality in porphyrin metabolism influence ALA-D activity, and it has few clinical applications.To elucidate the regulation of 15-aminolevulinic acid dehydratase (ALA-D) activity, we compared the ALA-D activity and protoporphyrin levels in erythrocytes among three different species. The values for erythrocyte ALA-D activity were highest in the guinea pig, followed by man and the mouse. Erythrocyte protoporphyrin levels showed a similar tendency. A definite correlation exists between ALA-D activity and protoporphyrin levels in erythrocytes. From this data, it is speculated that ALA-D activity in normal metabolism is a marker of heme synthesis.

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Porphobilinogen as a Porphyrin Precursor, and Interconversion of Porphyrins, in a Tissue System

Cited by 115 publications

References 10 publications

Pharmacology of the Porphyrins and Porphobilinogen

Pharmacology of the Porphyrins and Porphobilinogen

In Vitro Pyrrole and Porphyrin Synthesis in Lead Poisoning and Iron Deficiency*

Analyses of δ‐Aminolevulinic Acid Dehydratase Activity and Protoporphyrin Levels in Erythrocytes among Three Different Species

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