Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications

Guillem-Marti, Jordi; Cinca, N.; Punset, Miquel; Cano, I.G.; Gil, F.J.; Guilemany, J.M.; Dosta, S.

doi:10.1016/j.colsurfb.2019.04.048

Cited by 49 publications

(31 citation statements)

References 86 publications

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“…The CAS fragment has been described to promote cell proliferation in smooth Ti surfaces [31]. Moreover, Guillem-Marti et al have studied the adhesion and proliferation of SaOS-2 cells on smooth Ti, obtaining similar results on adhesion and proliferation than the Ti scaffolds used as a control in this work, which demonstrates the biocompatibility of uncoated Ti [46,57]. In this study, however, the Ti surface presents pores that have been shown to affect protein adsorption processes through capillary forces and increased specific surface area [58].…”

Section: In Vitro Cell Responsesupporting

confidence: 64%

Titanium Scaffolds by Direct Ink Writing: Fabrication and Functionalization to Guide Osteoblast Behavior

Vidal

Torres

Guillem-Marti

et al. 2020

Metals

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Titanium (Ti) and Ti alloys have been used for decades for bone prostheses due to its mechanical reliability and good biocompatibility. However, the high stiffness of Ti implants and the lack of bioactivity are pending issues that should be improved to minimize implant failure. The stress shielding effect, a result of the stiffness mismatch between titanium and bone, can be reduced by introducing a tailored structural porosity in the implant. In this work, porous titanium structures were produced by direct ink writing (DIW), using a new Ti ink formulation containing a thermosensitive hydrogel. A thermal treatment was optimized to ensure the complete elimination of the binder before the sintering process, in order to avoid contamination of the titanium structures. The samples were sintered in argon atmosphere at 1200 °C, 1300 °C or 1400 °C, resulting in total porosities ranging between 72.3% and 77.7%. A correlation was found between the total porosity and the elastic modulus of the scaffolds. The stiffness and yield strength were similar to those of cancellous bone. The functionalization of the scaffold surface with a cell adhesion fibronectin recombinant fragment resulted in enhanced adhesion and spreading of osteoblastic-like cells, together with increased alkaline phosphatase expression and mineralization.

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Section: In Vitro Cell Responsesupporting

confidence: 64%

Titanium Scaffolds by Direct Ink Writing: Fabrication and Functionalization to Guide Osteoblast Behavior

Vidal

Torres

Guillem-Marti

et al. 2020

Metals

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“…The MMCs coatings can have various applications. Their frequent function is regeneration of surfaces [121], electrical conductivity [122], corrosion resistance [123], wear resistance [124], biomedical [125], etc. These coatings combine elevated wear-resistance, machinability, and reasonable thermal conductivity.…”

Section: Low Pressure Cold Spraying and High Pressure Cold Sprayingmentioning

confidence: 99%

Review of Functionally Graded Thermal Sprayed Coatings

et al. 2020

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The paper briefly describes major thermal spray techniques used to spray functionally graded coatings such as atmospheric plasma spraying, high velocity oxy-fuel spraying, suspension and solution precursor plasma spraying, and finally low and high pressure cold gas spray method. The examples of combined spray processes as well as some examples of post spray treatment including laser and high temperature treatments or mechanical one, are described. Then, the solid and liquid feedstocks used to spray and their properties are shortly discussed. The reviewed properties of functional coatings include: (i) mechanical (adhesion, toughness, hardness); (ii) physical (porosity, thermal conductivity and diffusivity, thermal expansion, photo-catalytic activity), and; (iii) bioactivity and simulated body fluid (SBF) corrosion. These properties are useful in present applications of functionally graded coatings as thermal barriers, the bioactive coatings in prostheses, photo-catalytic coatings in water treatment, coatings used in printing industry (anilox and corona rolls). Finally, some of the future possible fields of functional thermal sprayed coatings applications are discussed, e.g., to coat polymer substrates or to use the cheap technology of low pressure cold gas spray method instead of expensive technology of vacuum plasma spraying to obtain bond coatings.

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“…способствует оптимальному образованию кости и улучшенной фиксации с костным ложем по сравнению титановым имплантатом без покрытия [56,57]. Это связано с тем, что напыляемый ГА представляет собой фосфат кальция, аналогичный неорганическому компоненту кости, хотя в нем отсутствует несколько замещающих ионов [58].…”

Section: гидроксиапатитовое покрытиеunclassified

Cementless Hip Implants: History and Current Status of the Issue

Шубняков

Риахи

Шубняков³

et al. 2020

Traumatology and Orthopedics of Russia

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Background. Total hip arthroplasty is an effective type of surgery with excellent survival rates of modern implants. From the very beginning of the widespread introduction of total hip arthroplasty, the cement technique of components fixing prevailed. However, many researchers associated the development of osteolysis and the following loosening with the reaction to cement. The subsequent studies clarified the situation regarding the nature of osteolysis, but there remained the problem of insufficient stability of the cemented stems to withstand the penetration of polyethylene wear particles into the distal part of the stem with the development of loosening. An ideal endoprosthesis should ensure the normal hip biomechanics, joint painless functioning and improve the quality of life of the patient without the need for revision. The optimal results of cementless femoral stems functioning depend on the achievement of initial stability, osseointegration and equable transmission of tension onto the femur. There are many factors that influence osseointegration processes and the subsequent behavior of the implant. Understanding these factors is the key to choosing the optimal implant for a particular patient, taking into account the anatomical features of the femur.The purpose of this article is to discuss upon the literature review the application of cementless femoral components, the possible causes of failure and its prevention from the point of view of the evidence-based practice.Materials. The search was conducted in the PubMed, eLIBRARY databases and through the Web of Knowledge. Survival rates and prevalence of various implants in the structure of primary arthroplasty were estimated on the basis of annual reports of a number of national registries, as well as the hip arthroplasty registry of the Vreden National Medical Research Center of Traumatology and Orthopedics. Among the factors discussed are the properties of the components material, the form of the implants, surface properties, and the influence of the anatomical features of the femur. Additionally, the most used types of cementless femoral components were assessed.Conclusion. Cementless femoral components demonstrated the excellent long-term survival and functional results. The currently prevailing type of the prosthesis intimate attachment to the bone is the biological fixation, especially in groups of young patients. Future studies of cementless implants should necessarily take into account the patient’s age, level of activity, type of bone canal, the presence of deformities, and the friction pair used. This will make it possible to draw clearer conclusions in what clinical situation it is advisable to use the femoral components of a particular design.

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Porous titanium-hydroxyapatite composite coating obtained on titanium by cold gas spray with high bond strength for biomedical applications

Cited by 49 publications

References 86 publications

Titanium Scaffolds by Direct Ink Writing: Fabrication and Functionalization to Guide Osteoblast Behavior

Titanium Scaffolds by Direct Ink Writing: Fabrication and Functionalization to Guide Osteoblast Behavior

Review of Functionally Graded Thermal Sprayed Coatings

Cementless Hip Implants: History and Current Status of the Issue

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