Porous titanium granules promote bone healing and growth in rabbit tibia peri‐implant osseous defects

Wohlfahrt, Johan Caspar; Monjo, Marta; Rønold, Hans Jacob; Aass, ­Anne Merete; Ellingsen, Jan Eirik; Lyngstadaas, Ståle Petter

doi:10.1111/j.1600-0501.2009.01813.x

Cited by 48 publications

(71 citation statements)

References 32 publications

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“…Eight prospective clinical studies [22,23,28,29,34,36,38,39], seven case series [24-27,30,33,35], and three randomized clinical trials (RCTs) [31,32,37] were included for the final review. A total of 528 patients (713 implants) were treated.…”

Section: Resultsmentioning

confidence: 99%

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Surgical Regenerative Treatments for Peri-Implantitis: Meta-analysis of Recent Findings in a Systematic Literature Review

Daugėla¹,

Cicciù²,

Saulačić

2016

JOMR

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ObjectivesThe purpose of the present study was to systematically review the literature on the surgical regenerative treatment of the peri-implantitis and to determine an effective therapeutic predictable option for their clinical management.Material and MethodsThe study searched MEDLINE and EMBASE databases from 2006 to 2016. Clinical human studies that had reported changes in probing depth (PD) and/or bleeding on probing (BOP) and/or radiologic marginal bone level (RBL) changes after peri-implantitis surgical treatment at 12-month follow-up or longer were included accordingly to PRISMA guidelines.ResultsThe initial search obtained 883 citations. After screening and determination of eligibility, 18 articles were included in the review. The meta-analysis of selected studies revealed that the weighted mean RBL fill was 1.97 mm (95% confidence interval [CI] = 1.58 to 2.35 mm), PD reduction was 2.78 mm (95% CI = 2.31 to 3.25 mm), and BOP reduced by 52.5% (95% CI = 41.6 to 63.1%). Defect fill in studies using and not using barrier membranes for graft coverage was 1.86 mm (95% CI = 1.36 to 2.36 mm) and 2.12 mm (95% CI = 1.46 to 2.78 mm) correspondingly. High heterogeneity among the studies regarding defects morphology, surgical protocols, and selection of biomaterials were found.ConclusionsAll included studies underlined an improvement of clinical conditions after the surgical regenerative treatment of peri-implantitis, however, there is a lack of scientific evidence in the literature regarding the superiority of the regenerative versus non-regenerative surgical treatment. The presence of a barrier membrane or submergence in the regenerative procedure does not seem to be fundamental in order to obtain clinical success of the surgery.

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Section: Resultsmentioning

confidence: 99%

“…The mean age of the patients was 61 years (ranged from 20 to 83 years) with the mean observation period of 37 months (ranging from 12 to 236 months). Eleven studies [23-25,27,29,31,32,35-37,39] reported smoking status of the patients, ranging from 14% [39] to 72% [36]. The summarized individual study characteristics are described in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Surgical Regenerative Treatments for Peri-Implantitis: Meta-analysis of Recent Findings in a Systematic Literature Review

Daugėla¹,

Cicciù²,

Saulačić

2016

JOMR

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“…There were only 60% of the Tigran cases which showed complete re-establishment of the buccal cortical defect, which can be explained by that Tigran granules may need a longer healing period like in CERA-MENT™|BONE VOID FILLER. Tigran is reported to be osteoconductive in experimental osseous defects in conjunction with titanium implants [18]. The retrograde material in this experiment was intermediate restorative material, IRM and it has been reported to be a suitable rootend filling material in periapical surgery procedures [4,19].…”

Section: Discussionmentioning

confidence: 96%

Evaluation of 4 different bone graft substitutes and autogenous bone grafting in root-end resection osteotomies after retrograde root-filling with Intermediate Restorative Material (IRM): An experimental study in dogs

Wälivaara¹,

Abrahamsson²

2013

OJST

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“…14,15 Titanium particles have increasingly used for augmentation procedures, such as sinus lifting, socket preservation, and in the treatment of peri-implantitis. 6,8,[15][16][17] Tissue integration and both two and three-dimensional bone regeneration with Ti particles, however, still need to be explored.…”

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confidence: 98%

Effect of Porous Titanium Granules on Bone Regeneration and Primary Stability in Maxillary Sinus

Dursun

Eratalay

et al. 2016

Journal of Craniofacial Surgery

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The aim of this randomized controlled study was to comparatively analyze the new bone (NB), residual bone, and graft-bone association in bone biopsies retrieved from augmented maxillary sinus sites by histomorphometry and microcomputed tomography (MicroCT) in a split-mouth model to test the efficacy of porous titanium granules (PTG) in maxillary sinus augmentation. Fifteen patients were included in the study and each patient was treated with bilateral sinus augmentation procedure using xenograft (equine origine, granule size 1000-2000 μm) and xenograft (1 g) + PTG (granule size 700-1000 μm, pore size >50 μm) (1 g), respectively. After a mean of 8.4 months, 30 bone biopsies were retrieved from the implant sites for three-dimensional MicroCT and two-dimensional histomorphometric analyses. Bone volume and vital NB percentages were calculated. Immediate after core biopsy, implants having standard dimensions were placed and implant stability quotient values were recorded at baseline and 3 months follow-up. There were no significant differences between groups according to residual bone height, residual bone width, implant dimensions, and implant stability quotient values (baseline and 3 months). According to MicroCT and two-dimensional histomorphometric analyses, the volume of newly formed bone was 57.05% and 52.67%, and 56.5% and 55.08% for xenograft + PTG and xenograft groups, respectively. No statistically significant differences found between groups according to NB percentages and higher Hounsfield unit values were found for xenograft + PTG group. The findings of the current study supports that PTG, which is a porous, permanent nonresorbable bone substitute, may have a beneficial osteoconductive effect on mechanical strength of NB in augmented maxillary sinus.

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Porous titanium granules promote bone healing and growth in rabbit tibia peri‐implant osseous defects

Abstract: The results suggest that PTG and WPTG are both osteoconductive materials that can be used to promote bone formation in osseous defects adjacent to titanium implants without hampering implant osseointegration.

Cited by 48 publications

References 32 publications

Surgical Regenerative Treatments for Peri-Implantitis: Meta-analysis of Recent Findings in a Systematic Literature Review

Surgical Regenerative Treatments for Peri-Implantitis: Meta-analysis of Recent Findings in a Systematic Literature Review

Evaluation of 4 different bone graft substitutes and autogenous bone grafting in root-end resection osteotomies after retrograde root-filling with Intermediate Restorative Material (IRM): An experimental study in dogs

Effect of Porous Titanium Granules on Bone Regeneration and Primary Stability in Maxillary Sinus

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