Porous silicon nanoparticles as efficient sensitizers for sonodynamic therapy of cancer

Benzoic‐Imine‐Based Physiological‐pH‐Responsive Materials for Biomedical Applications

“…[89] Besides pH sensitivity,a dditional stimuli groups, such as the redox-responsive disulfide bond, are frequently introduced into drug-delivery systems to furthert rigger the drug release, for example, by using the intracellular reducing environment in cancercells. [90,91] Recently,disulfide and benzoic imine bonds have been selectively capped at the two corresponding ends of at umor-targeting peptide, RGDFFFFC. Mesoporouss ilica nanoparticles were treated with the modified peptide, followed by af urtherc onnection with poly(ethylene glycol).…”

Gold nanoparticle‐induced sonosensitization enhances the antitumor activity of ultrasound in colon tumor‐bearing mice

“…Some nanomaterials have been demonstrated to possess sonosensitizing properties, which can be implemented to enhance the therapeutic effects of ultrasound . Furthermore, compared to bulk sonosensitizing materials, nanomaterials are able to accumulate passively and be retained preferentially at the tumor site through an enhanced permeability and retention (EPR) effect arising from the leaky vasculature and ineffective lymphatic drainage of the tumor tissue.…”

“…9,10 Some nanomaterials have been demonstrated to possess sonosensitizing properties, which can be implemented to enhance the therapeutic effects of ultrasound. [11][12][13][14] Furthermore, compared to bulk sonosensitizing materials, nanomaterials are able to accumulate passively and be retained preferentially at the tumor site through an enhanced permeability and retention (EPR) effect arising from the leaky vasculature and ineffective lymphatic drainage of the tumor tissue. Therefore, the preferential loading of the tumor with these nanosonosensitizers and the subsequent ultrasound irradiation may provide a selective ultrasound therapy through localizing the thermal and mechanical damages of ultrasound to the tumor site, meanwhile preserving the neighboring healthy tissue from unwanted damage.…”

New Medical Technology – Functional Microwave Thermography: Experimental Study

“…It allowed us to develop a method of functional microwave thermography (FMT), which is currently at the stage of preclinical testing and patent registration [4,5]. Note, the temperature monitoring should be useful for various therapeutic modalities of mild cancer treatments, which can be realized by using biocompatible and biodegradable nanoparticles based on silicon [6,7]. Prior the experiments the skin of mouse was preliminarily prepared (sheared fur), and then with the aid of the special cream it was depilated the contact surface of the antenna of radio-sensor and skin.…”