Porous Silicon for Microdevices and Microsystems

Stefano, Luca De; Rea, Ilaria

doi:10.1007/978-3-319-04508-5_81-1

Handbook of Porous Silicon 2014

DOI: 10.1007/978-3-319-04508-5_81-1

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Porous Silicon for Microdevices and Microsystems

Luca De Stefano¹,

Ilaria Rea²

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2015

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Cited by 1 publication

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References 56 publications

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“…[ 16,27,39 ] The integration of PSi-based biosensors with microfl uidic systems has gained considerable interest in recent years. [ 38,40,41 ] The incorporation of PSi biosensors into lab-on-a-chip devices has shown great promise for sensitive and real-time detection of DNA, offering signifi cant advantages in terms of high throughput, small sample volumes, and rapid operation time. [ 37,38,40 ] In addition to these conventional advantages attributed to miniaturization, microfl uidic lab-on-a-chip platforms…”

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confidence: 99%

Oxidized Porous Silicon Nanostructures Enabling Electrokinetic Transport for Enhanced DNA Detection

Vilensky

Bercovici

Segal

2015

Adv Funct Materials

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Nanostructured porous silicon (PSi) is a promising material for the label-free detection of biomolecules, but it currently suffers from limited applicability due to poor sensitivity, typically in micromolar range. This work presents the design, operation concept, and characterization of a novel microfl uidic device and assay that integrates an oxidized PSi optical biosensor with electrokinetic focusing for a highly sensitive label-free detection of nucleic acids. Under proper oxidation conditions, the delicate nanostructure of PSi can be preserved, while providing suffi cient dielectric insulation for application of high voltages. This enables the use of signal enhancement techniques, which are based on electric fi elds. Here, the DNA target molecules are focused using an electric fi eld within a fi nite and confi ned zone, and this highly concentrated analyte is delivered to an on-chip PSi Fabry-Pérot optical transducer, prefunctionalized with capture probes. Using refl ective interferometric Fourier transform spectroscopy real-time monitoring, a 1000-fold improvement in limit of detection is demonstrated compared to a standard assay, using the same biosensor. Thus, a measured limit of detection of 1 × 10 −9 M is achieved without compromising specifi city. The concepts presented herein can be readily applied to other ionic targets, paving way for the development of other highly sensitive chemical and biochemical assays.

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mentioning

confidence: 99%

Oxidized Porous Silicon Nanostructures Enabling Electrokinetic Transport for Enhanced DNA Detection

Vilensky

Bercovici

Segal

2015

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

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Porous Silicon for Microdevices and Microsystems

Cited by 1 publication

References 56 publications

Oxidized Porous Silicon Nanostructures Enabling Electrokinetic Transport for Enhanced DNA Detection

Oxidized Porous Silicon Nanostructures Enabling Electrokinetic Transport for Enhanced DNA Detection

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