Porous Silicon-based Electrochemical Biosensors

Setzu, S.; Monduzzi, Maura; Mula, Guido; Salis, Andrea

doi:10.5772/17068

Cited by 8 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, pSi has been successfully applied to the development of optical and electrical sensors. Optical sensors are commonly based on monitoring the shift in the interferometric reflectance fringe pattern caused by changes in the average refractive index [4], whereas electrical sensors usually rely on measuring either conductance or capacitance changes [4]. However, little research has been done on the development of electrochemical sensors based on pSi, which present some interesting features including high sensitivity, low cost, relatively simple instrumentation, easy miniaturization and portability [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Stabilization methods based on pSi oxidation through thermal, chemical or anodic oxidation treatments promote the growth of the insulating SiO2 layer which limits the performance of certain electrochemical transduction techniques. Other approaches that have been explored to both stabilize and modify the electrical properties of pSi, making it more fit for electrochemical sensing, include various thin film coating methods based on metals or conductive polymers [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Carbon-stabilized porous silicon as novel voltammetric sensor platforms

Pérez‐Ràfols

Guo

Alba

et al. 2021

Electrochimica Acta

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carbon-stabilized porous silicon as novel voltammetric sensor platforms

Pérez‐Ràfols

Guo

Alba

et al. 2021

Electrochimica Acta

View full text Add to dashboard Cite

“…In addition, PSi is easily prepared either in powder [17] or wafer [18], it has an excellent biocompatibility [19] and has flexibility in controlling the surface chemistry [20,21] which make this material ideal for the immobilization of enzymes [22]. However, PSi amperometric biosensors didn't get much attention most likely due its low conductivity and weak stability [23]. As it well known, in electrochemical biosensors the transductor must have high conductivity, robust stability, a large and effective electrochemical area, and good cycling performance.…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase Modified Porous Silicon for Electrochemical Measurement of Total Active Immobilized Enzyme Amount and Effective Malathion Detection

Khaldi¹,

Sam²,

Gabouze³

2020

I2M

View full text Add to dashboard Cite

An amperometric method to measure the total amount of active and inhibited immobilized Acetylcholinesterase enzyme (AChE) and the quantification of AChE inhibitors was realized. In this approach porous silicon (PSi) surface was used as a matrix for AChE immobilization and Boron doped polycrystalline diamant (BDPD) was used as working electrode for the electrochemical measurements. The covalent immobilization of AChE from electric eel was achieved on amine functionalized PSi surface previously decorated with Au particles. This surface is suitable for a stable attachment of AChE enzyme. The amperometric detection of AChE activity at Boron doped polycrystalline diamond electrode is based on the oxidation of thiocholine, the enzymatic reaction product of immobilized AChE in the presence of the substrate acetylthiocholine chlorid (ATCl) and this without the need to further modify the BDPD surface or the use of other reagents. The concentration of immobilized active AChE enzymes was estimated to Γ≈ 1.8 10 12 AChE cm -2 by means of a calibration curve. Michaelis constant was assessed with a Km of 4.3 10 -4 M. Finally, the electrochemical quantification and detection of Malathion shows a good linear calibration curve where the concentration of Malathion range is from 2 to 6 nM within 6 minutes after inhibitor addition.

show abstract

“…Among the candidate materials, Porous silicon (PSi) has drawn the attention of many researchers, besides its possibility to integrate PSi directly with the standard silicon technologies, and its present applications span from biomedicine to bio-sensing and from photonics to photovoltaic devices [1]. Four major causes that have led to the continued widespread attention to PSi are the following [2]:…”

Section: Introductionmentioning

confidence: 99%

Study of Electrical Properties of Photodetector

Mousa¹,

Nawfal²

2017

JEES

View full text Add to dashboard Cite

In this paper porous silicon sample that can be used as a photodetector was prepared at fixed etching time of 15min and different etching current density (15, 17, 19 and 21) mA/cm 2 . Electrical properties of Al / PSi / p-Si /Al photodetector were studied. We found that the I-V characteristics dependence of the etching current density relates to the PSi pores development, where the pore diameter in PSi structure might get enlarged due to the enhancement of the etching current density. The ideality factor ranges around (6.8-4.2) while the barrier height decreased with the increasing etching current density and the etching time as the interface layer between PSi/c-Si has large amount of pinning. Then the C-V characteristics of the sandwich structure are described. When the etching current densities are increased, it reduces the capacitance of the PSi layer. It thus increases the thickness of the depletion region which in turn results in development of built-in potential.

show abstract

Porous Silicon-based Electrochemical Biosensors

Cited by 8 publications

References 80 publications

Carbon-stabilized porous silicon as novel voltammetric sensor platforms

Carbon-stabilized porous silicon as novel voltammetric sensor platforms

Acetylcholinesterase Modified Porous Silicon for Electrochemical Measurement of Total Active Immobilized Enzyme Amount and Effective Malathion Detection

Study of Electrical Properties of Photodetector

Contact Info

Product

Resources

About