Porous Se@Sio
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            Nanoparticles Improve Oxidative Injury to Promote Muscle Regeneration Via Modulating Mitochondria

Yang, Yuxia; Liu, Mingsheng; Liu, Xijian; Zhang, Yucheng; Hu, Yangyang; Gao, Rangshan; Pang, Erkai; Hou, Lei; Wang, Jingcheng; Fei, Wenyong

doi:10.2217/nnm-2022-0173

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…The targeted polyphenol delivery by drug carriers created using nanotechnology that guarantees target specificity can overcome the drawbacks, and boost the bioavailability and stability of the therapeutic molecules in vivo [ 251 ]. Moreover, researches show that porous Se@SiO2 nanoparticles which would slowly release selenium could improve oxidative injury to promote muscle regeneration via modulating mitochondria [ 253 ]. CoQ’s lack of aqueous solubility and poor oral bioavailability contribute to suboptimal results observed with respect to the effect of CoQ supplements on statin-induced myopathy.…”

Section: Therapeutic Strategies Targeting Mitochondria For Skeletal M...mentioning

confidence: 99%

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Chen¹,

Ji²,

Liu³

et al. 2023

J Transl Med

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Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle health, and damage to mitochondria can lead to a series of pathophysiological changes. Mitochondrial dysfunction can lead to skeletal muscle atrophy, and its molecular mechanism leading to skeletal muscle atrophy is complex. Understanding the pathogenesis of mitochondrial dysfunction is useful for the prevention and treatment of skeletal muscle atrophy, and finding drugs and methods to target and modulate mitochondrial function are urgent tasks in the prevention and treatment of skeletal muscle atrophy. In this review, we first discussed the roles of normal mitochondria in skeletal muscle. Importantly, we described the effect of mitochondrial dysfunction on skeletal muscle atrophy and the molecular mechanisms involved. Furthermore, the regulatory roles of different signaling pathways (AMPK-SIRT1-PGC-1α, IGF-1-PI3K-Akt-mTOR, FoxOs, JAK-STAT3, TGF-β-Smad2/3 and NF-κB pathways, etc.) and the roles of mitochondrial factors were investigated in mitochondrial dysfunction. Next, we analyzed the manifestations of mitochondrial dysfunction in muscle atrophy caused by different diseases. Finally, we summarized the preventive and therapeutic effects of targeted regulation of mitochondrial function on skeletal muscle atrophy, including drug therapy, exercise and diet, gene therapy, stem cell therapy and physical therapy. This review is of great significance for the holistic understanding of the important role of mitochondria in skeletal muscle, which is helpful for researchers to further understanding the molecular regulatory mechanism of skeletal muscle atrophy, and has an important inspiring role for the development of therapeutic strategies for muscle atrophy targeting mitochondria in the future.

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Section: Therapeutic Strategies Targeting Mitochondria For Skeletal M...mentioning

confidence: 99%

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Chen¹,

Ji²,

Liu³

et al. 2023

J Transl Med

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show abstract

“…Based on this, we can prepare drugs with antioxidant properties such as selenium, 184 melatonin, 185 angiotensin II antagonist, 178 and acetylcysteine 178 by wrapping them with nanomaterials and using MNs as a carrier to improve the oxidative environment at the site of injury. Yu–Xia Yang et al 186 prepared porous Se@SiO 2 NP by encapsulating Se element with SiO 2 , allowing the slow release of Se from the porous material to attenuate its toxicity. Also, it has been confirmed that the mitochondrial function and high level of oxidative environment were improved in the rat models via intraperitoneal injection.…”

Section: Application Of Mns In the Musculoskeletal Systemmentioning

confidence: 99%

Transdermal drug delivery via microneedles for musculoskeletal systems

Zheng¹,

Xie²,

Ling³

et al. 2023

J. Mater. Chem. B

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The Role of Mitochondria in Mediation of Skeletal Muscle Repair

Paez

Pitzer

2023

Muscles

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Musculoskeletal health is directly linked to independence and longevity, but disease and aging impairs muscle mass and health. Complete repair after a pathological or physiological muscle injury is critical for maintaining muscle function, yet muscle repair is compromised after disuse, or in conditions such as metabolic diseases, cancer, and aging. Regeneration of damaged tissue is critically dependent upon achieving the optimal function of satellite cells (muscle stem cells, MSCs). MSC remodeling in muscle repair is highly dependent upon its microenvironment, and metabolic health of MSCs, which is dependent on the functional capacity of their mitochondria. Muscle repair is energy demanding and mitochondria provide the primary source for energy production during regeneration. However, disease and aging induce mitochondrial dysfunction, which limits energy production during muscle regeneration. Nevertheless, the role of mitochondria in muscle repair likely extends beyond the production of ATP and mitochondria could provide potentially important regulatory signaling to MSCs during repair from injury. The scope of current research in muscle regeneration extends from molecules to exosomes, largely with the goal of understanding ways to improve MSC function. This review focuses on the role of mitochondria in skeletal muscle myogenesis/regeneration and repair. A therapeutic strategy for improving muscle mitochondrial number and health will be discussed as a means for enhancing muscle regeneration. Highlights: (a). Mitochondrial dysfunction limits muscle regeneration; (b). Muscle stem cell (MSC) function can be modulated by mitochondria; (c). Enhancing mitochondria in MSCs may provide a strategy for improving muscle regeneration after an injury.

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Porous Se@Sio ₂ Nanoparticles Improve Oxidative Injury to Promote Muscle Regeneration Via Modulating Mitochondria

Cited by 3 publications

References 52 publications

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Transdermal drug delivery via microneedles for musculoskeletal systems

The Role of Mitochondria in Mediation of Skeletal Muscle Repair

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Porous Se@Sio 2 Nanoparticles Improve Oxidative Injury to Promote Muscle Regeneration Via Modulating Mitochondria

Cited by 3 publications

References 52 publications

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Mitochondrial dysfunction: roles in skeletal muscle atrophy

Transdermal drug delivery via microneedles for musculoskeletal systems

The Role of Mitochondria in Mediation of Skeletal Muscle Repair

Contact Info

Product

Resources

About

Porous Se@Sio ₂ Nanoparticles Improve Oxidative Injury to Promote Muscle Regeneration Via Modulating Mitochondria