Porous polylactide prepared by the delocalized crazing as a template for nanocomposite materials

Трофимчук, Е. С.; Москвина, М. А.; Ivanova, Оlga А.; Potseleev, Vladislav V.; Demina, Varvara A.; Никонорова, Н. И.; Bakirov, A. V.; Sedush, Nikita G.; Чвалун, С. Н.

doi:10.1016/j.mencom.2020.03.013

Cited by 19 publications

(7 citation statements)

References 18 publications

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“…After heating under these conditions, the degree of PLA crystallinity determined by differential scanning calorimetry (DSC) was about 30-40%, and the average crystallite size determined from X-Ray Diffraction (XRD) data were 14-16 nm (as coherent scattering region). It was previously suggested [21] that uniaxial stretching of such partially crystalline PLA films in 95% ethanol proceeded by the mechanism of delocalized crazing. Figure 2 shows the dependence of the effective volume porosity of the PLA crystalline film versus the tensile strain.…”

Section: Resultsmentioning

confidence: 96%

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Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

Potseleev,

Uspenskii,

Trofimchuk

et al. 2023

IJMS

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In this study, approaches to the synthesis of complex compound of gold with cysteine [AuCys]n for measuring absorbed dose in boron neutron capture therapy (BNCT) were developed. The dependence of the complex particle size on pH were established. Nanocomposite materials based on polylactide containing [AuCys]n particles with an average size of about 20 nm were obtained using the crazing mechanism. The structure of obtained materials was studied by electron microscopy. The release kinetics of [AuCys]n from polymer matrix were investigated. Release of [AuCys]n from the volume of the polymeric matrix had a delayed start—this process began only after 24 h and was characterized by an effective rate constant of 1 μg/h from a 20 mg composite sample. At the same time, in vitro studies showed that the concentration of 6.25 μg/mL was reliably safe and did not reduce the survival of U251 and SW-620 cells.

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Section: Resultsmentioning

confidence: 96%

“…In this work, polylactide (PLA) was chosen as a polymer matrix, and the compound of gold with cysteine [AuCys] n was chosen as a chelate compound. PLA is a polymer of lactic acid, which is extensively used in pharmaceutical and medical applications due to its biocompatibility and biodegradability [21,22].…”

Section: Introductionmentioning

confidence: 99%

Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

Potseleev,

Uspenskii,

Trofimchuk

et al. 2023

IJMS

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“…Trofimchuk et al have carried out a lot of investigations in the field of exploration of PLA crazing [ 130 , 131 , 132 , 133 ]. In particular, the effect of different media (air and adsorption-active liquids) during uniaxial stretching on the formation of crazes in PLA was studied in [ 131 ].…”

Section: Structural Rearrangement Of Pla Chainsmentioning

confidence: 99%

Recent Approaches to the Plasticization of Poly(lactic Acid) (PLA) (A Review)

Mastalygina,

Aleksanyan

2023

Polymers

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Poly(lactic acid) (PLA) is a polyester attracting growing interest every year in different application fields, such as packaging, cosmetics, food, medicine, etc. Despite its significant advantages, it has low elasticity that may hinder further development and a corresponding rise in volume of consumption. This review opens a discussion of basic approaches to PLA plasticization. These considerations include copolymerization and blending with flexible polymers, introducing oligomers and low-molecular additives, as well as structural modification. It was demonstrated that each approach has its advantages, such as simplicity and low cost, but with disadvantages, including complex processing and the need for additional reagents. According to the analysis of different approaches, it was concluded that the optimal option is the application of copolymers as the additives obtained via reactive mixing to PLA and its blends with other polymers.

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“…После нагрева при данных условиях степень кристалличности ПЛ составила порядка 30-40 %, средний размер кристаллитов -14-16 нм (ОКР). Одноосная деформация подобных частично кристаллических пленок ПЛ в среде 95 %-го этанола протекает по механизму делокализованного крейзинга [8]. В этом случае зарождение и развитие пор происходит достаточно однородно по всему объему в межкристаллитных аморфных областях.…”

Section: результаты исследованийunclassified

“…2 (а, б и в) представлены СЭМ-и ПЭМизображения полученных нанокомпозитов. На них хорошо видно, что в процессе растяжения происходит образование достаточно однородной структуры в объеме полимерной пленки, которая, как ранее было показано [8], обладает открытопористой структурой, которую можно заполнять по всему объему наполнителем. Образование [AuCys]n в пленках полилактида было подтверждено электронограммой нанокомпозита (рис.…”

Section: результаты исследованийunclassified

Synthesis of gold complex compounds for cancer diagnostics and obtaining nanocomposite materials based on polylactide

Potseleev,

Trofimchuk,

Uspenskii

2023

TKSC RAS

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Approaches to the synthesis of a drug for photon-capture therapy based on the complex compound of gold with cysteine [Au(I)-Cys]n have been developed. The dependence of the particle sizes of the complex on pH was established. Using the crazing mechanism, nanocomposite materials based on polylactide and containing [Au(I)-Cys]n particles with an average size of about 10 nm were obtained. The obtained materials were studied using electron microscopy and their structure was established.

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Porous polylactide prepared by the delocalized crazing as a template for nanocomposite materials

Cited by 19 publications

References 18 publications

Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

Nanocomposite Materials Based on Polylactide and Gold Complex Compounds for Absorbed Dose Diagnostics in BNCT

Recent Approaches to the Plasticization of Poly(lactic Acid) (PLA) (A Review)

Synthesis of gold complex compounds for cancer diagnostics and obtaining nanocomposite materials based on polylactide

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