Porous poly(N-isopropylacrylamide) gels polymerized in mixed solvents of water and N,N-dimethylformamide

Tokuyama, Hideaki; Ishihara, Noriaki; Sakohara, Shuji

doi:10.1007/s00289-008-0961-3

Cited by 27 publications

(29 citation statements)

References 34 publications

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“…Similar types of results have also been reported in the literature for mixtures of water and other water-miscible solvent systems. 6,9,20,21,[25][26][27][28] Moreover, the swelling ratio values of all of the gels except the one prepared in water (run X 0 ) are observed at a minimum ($ 2) at about 38 C, whereas the same for the gel prepared in water (run X 0 ) is observed at around 35 C. This is due to the formation of macroporous cross-linked gel in the methanol-water mixtures. This eventually leads to the higher retention power of water within the gel matrices.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization, and drug release properties of poly(N‐isopropylacrylamide) gels prepared in methanol–water cononsolvent medium

Biswas

Patel

Vishwakarma

et al. 2012

J of Applied Polymer Sci

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Poly(N‐isopropylacrylamide) (PNIPAM) hydrogels were simply prepared by free radical polymerization in different methanol–water mixture. A scanning electron microscopy study revealed that the freeze‐dried hydrogels were macroporous. The swelling ratios in water at 20°C of the resulting hydrogels followed the order: X0.43>X0.21>X0.76 ≈ X0.57>X0.31>X0.13>X0.06>X0, where Xm denotes a gel prepared in a methanol–water mixture with m mole fraction of methanol (xm). Below the lower critical solution temperature, the swelling ratio values of all of the hydrogels gradually decreased with the increase in the temperature. The complete collapse of the PNIPAM chain of all the gels occurred at about 38°C, whereas the same was observed at about 35°C for the conventional gel prepared in water. The swelling ratio values of all the PNIPAM gels in the methanol–water mixtures with different xm values at 20°C passed through a minimum in the cononsolvency zone. The deswelling rates of the hydrogels decreased in the following order: X0.43> X0.31> X0.21> X0.57> X0.76 ≈ X0.13> X0.06> X0. The reswelling rates of these hydrogels decreased in the following order: X0> X0.31> X0.06 ≈ X0.13 > X0.76> X0.57> X0.21> X0.43. The release rates of the Tramadol Hydrochloride drug at 37°C from the drug‐loaded hydrogels were almost same for all of the hydrogels. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

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Section: Resultsmentioning

confidence: 99%

Synthesis, characterization, and drug release properties of poly(N‐isopropylacrylamide) gels prepared in methanol–water cononsolvent medium

Biswas

Patel

Vishwakarma

et al. 2012

J of Applied Polymer Sci

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“…Figure 2 shows the effect of contact time to amount of Cr(VI) adsorbed onto four types of adsorbents. After a period of time, the hyperosmotic pressure of the K 2 CrO 4 solution tended to collapse the gel, 8 and then some channels disappeared and the adsorption amounts decreased. For Cr(VI) ions, all of the macroporous hydrogels were better than the conventional gels about both adsorption rate and adsorption amount.…”

Section: Adsorption Kinetics Of Cr(vi)mentioning

confidence: 99%

“…8 This opposite behavior was possibly caused by the poly(DMAEMA) curling when the electrostatic interaction between the cationic polyelectrolyte and Cr(VI) anion happened. In this experiment, the volume of the sorbents obviously shrinked in acid Cr(VI) solution and swollen in basic solution.…”

Section: Effect Of Initial Ph Value On Adsorption Processmentioning

confidence: 99%

“…So many researchers have contributed to solve the problem with new modified hydrogels. 8,9 Cheng et al used 2-(dimethylamino)ethyl methacrylate modified with 1-bromoalkanes as the adsorbent for Cr(VI) and showed clearly that diffusion of Cr(VI) ion into the pores of the adsorbent controlled the adsorption rate. 10 At present, some methods including preparation of comb-like hydrogels 11 and porous gels, [12][13][14] have been used to improve the response rate.…”

Section: Introductionmentioning

confidence: 99%

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Rapid removal of Cr(VI) ions from aqueous solutions by the macroporous poly(N, N′‐dimethylamino ethyl methacrylate) hydrogels

Zhu

Song

et al. 2012

J of Applied Polymer Sci

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To improve the adsorption ability of hexavalent chromium [Cr(VI)], the macroporous poly(N, N 0 -dimethylamino ethyl methacrylate) [poly(DMAEMA)] hydrogels were successfully fabricated by free-radical copolymerization in ethanol/water mixture using N, N 0 -dimethylamino ethyl methacrylate (DMAEMA) as the monomer, N, N 0 -methylenebisacrylamide (MBAA) as the crosslinker, and Na 2 SO 4 solution as the porogen. The effects of various parameters, such as the concentration of Na 2 SO 4 solutions, the dosage of MBAA, pH values, adsorption kinetic, and isotherm curves, were all investigated through systematic experiments. Scanning electron microscope (SEM) was employed to characterize the various pore structures. The experimental results showed that the influence of Na 2 SO 4 solution to the pore morphology in the matrix was significant. The poly(DMAEMA) hydrogels can effectively adsorb Cr(VI) ions in aqueous media, and the macroporous structures could obvious improve the response rate and adsorption capacity. These results prove that the macroporous poly(DMAEMA) gels can be treated as a potential material for environmental pollution control.

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“…Superabsorbent hydrogels such as macroporous poly(acrylamide-co-sodium methacrylate) can be obtained by use of the crosslinking polymerization method [12]. The rapid de-swelling of porous poly(N-isopropylacrylamide) hydrogels prepared using a free radical polymerization [13], Jia-Ming Chern and his coworkers reported preparation and swelling characterization of poly(N-isopropylacrylamide)-based porous hydrogels [14] and also Hideaki Tokuyama et al reported preparation of porous poly(N-Isopropylacrylamide) gel [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterizations of Macroporous Poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) Hydrogels for In Vitro Drug Release of Ranitidine Hydrochloride

Varaprasad

Reddy

Ravindra

et al. 2011

International Journal of Polymeric Materials

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Macroporous hydrogels were prepared with acrylamide (AM) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) as well as with anhydrous dextrose (AD) as porogen by crosslinking with N,N 1 -methylenebisacrylamide (MBA). The chemical structure of hydrogels is characterized by Fourier transform infrared (FTIR) spectroscopy. Morphological studies done by scanning electron microscopy (SEM) showed the macroporous nature of the hydrogels. Swelling studies of hydrogels were done in distilled water, in aqueous NaCl solution and in different pH solutions. In addition, drug release studies of selected macroporous hydrogels (DAMPS1, DAMPS4, DAMPSM1 and DAMPSM3) are also investigated.

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Porous poly(N-isopropylacrylamide) gels polymerized in mixed solvents of water and N,N-dimethylformamide

Cited by 27 publications

References 34 publications

Synthesis, characterization, and drug release properties of poly(N‐isopropylacrylamide) gels prepared in methanol–water cononsolvent medium

Synthesis, characterization, and drug release properties of poly(N‐isopropylacrylamide) gels prepared in methanol–water cononsolvent medium

Rapid removal of Cr(VI) ions from aqueous solutions by the macroporous poly(N, N′‐dimethylamino ethyl methacrylate) hydrogels

Synthesis and Characterizations of Macroporous Poly(acrylamide-2-acrylamido-2-methyl-1-propanesulfonic acid) Hydrogels for In Vitro Drug Release of Ranitidine Hydrochloride

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