Porous Organophosphine Ligand Polymers as Recyclable Ligands for the Synthesis of Isoindolinone Compounds

Abstract

Isoindolinone compounds were efficiently synthesized with Pd-metalated/porous organophosphorus ligand (Pd/ POL-PPh3) under heterogeneous conditions. Compared with homogeneous conditions, this method has higher yield, at the same time, the POL-PPh3 can be recycled, which reduces the cost of the reaction. In this reaction, POL-PPh3 has porous structure without obvious change during the reaction progress of the morphology, and this unique stability is the fundamental reason for the high activity and recyclability of POL-PPh3 as heterogeneous ligand.