“…Metal–organic frameworks (MOFs) as a group of porous crystalline materials are constructed by the autoassemblages of metal cations, salts, and polydentate organic ligands, which have attracted substantial interest for sensor design, catalysis, gas storage, and separations. − The extraordinary characterizations, including the exceptionally high surface area, various tailorable functional groups, and tunable pore size, make MOFs an excellent candidate for catalyst development. − Particularly, the metallic components contributed to the significant catalytic activity of MOFs to different substances. For example, Ni and Co ions with easy coordination with organic ligands have exhibited high catalytic activity for H 2 O 2 detection. − Additionally, bimetallic MOFs are composed of two different metal ions in the inorganic nodes, exhibiting the synergistic effect and enhanced catalytic activity in comparison with their monometallic counterparts, which could enable the extended applications for catalysis reaction. − On the other hand, metal nanoparticles with desirable electrical conductivity and biocompatibility were usually coated on the MOFs to improve the poor conductivity of the MOFs. , However, the composites exhibited some loss of catalytic activity, which was caused by the poor thermodynamical stability and the high surface energy, which is a pressing need to address.…”