Porous Microfluidic Devices – Fabrication and Applications

Jong, Jos de; Geerken, Maik J.; Lammertink, Rob G.H.; Weßling, Matthias

doi:10.1002/ceat.200600364

Cited by 22 publications

(14 citation statements)

References 16 publications

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“…The membrane imbedded chips combined the advantages of microfluidic chips with the characteristics of membranes, and had become versatile tools for basic biological research and biosensors development. As a crucial component, the membrane was assembled in the hybrid chip for sample filtration (Flachsbart et al 2006;Long et al 2007), enrichment (Hlushkou et al 2008;Metz et al 2004), extraction (Cai et al 2006), diffusion (Neeves and Diamond 2008) or emulsification (de Jong et al 2007). Membranes were also used as culturing supports or scaffold for tissue engineering (Kimura et al 2008;Ostrovidov et al 2004;Choi et al 2007;Hediger et al 2001).…”

Section: Introductionmentioning

confidence: 99%

A microfluidic chip for permeability assays of endothelial monolayer

Shao

et al. 2009

Biomed Microdevices

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Endothelial cell monolayer (EM), acting as a barrier between blood and tissue, plays an important role in pathophysiological processes. Here we describe a novel microfluidic chip that is applied for convenient and high throughput in vitro permeability assays of EM. The chip included a gradient generator and an array of cell culture chambers. A microporous membrane as a scaffold component was built between a polydimethylsiloxane (PDMS) layer and a glass substrate to grow EM. Cell culture chambers were separated by microchannels and microvalves. The concentration gradient of compound solutions could be generated automatically and affected EM in different chambers. The permeability of EM at different time with histamine stimulation was in situ measured by the fluorescence detection of the leaked tracer. The existence of continuous flow in the channels allowed EM in a dynamic microenvironment and increased the amount of tracer through the EM, comparing to transwell assays. According to the prototype chip, the chip with a bigger array of cell culture chambers could be achieved easily and applied in the high throughput screening for drugs.

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Section: Introductionmentioning

confidence: 99%

A microfluidic chip for permeability assays of endothelial monolayer

Shao

et al. 2009

Biomed Microdevices

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“…There are many examples where membranes can be used for gas-liquid contacting utilizing porous hydrophobic membranes (De Jong et al 2007). Since the gas phase is in contact with the liquid phase along the device, exchange of mass between the two phases is possible.…”

Section: Introductionmentioning

confidence: 99%

A microgrooved membrane based gas–liquid contactor

Jani

Weßling

Lammertink

2012

Microfluid Nanofluid

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This research presents an approach for applying microgrooved membranes for improved gas-liquid contacting. The study involves analysis of the performance of the microdevice by quantifying the flux enhancement for different membrane configurations. Two kinds of configurations, continuous and non-continuous grooves, were investigated. The microgrooves provide shear-free gasliquid interfaces, which result in local slip velocity at the gas-liquid interface. Exploiting this physical phenomenon, it is possible to reduce mass transport limitations in gasliquid contacting. An experimental study using grooved membranes suggests enhancement in flux up to 20-30 %. The flux enhancement at higher liquid flow rates is observed due to a partial shear-free gas-liquid interface. The performance of the membrane devices decreased with wetted microgrooves due to the mass transport limitations. The flow visualization experiments reveal wetting of the microgrooves at higher liquid flow rates. According to the numerical and experimental study, we have shown that microgrooved membranes can be employed to improve gas-liquid contacting processes.

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“…In c the solid lines correspond to fits to the data using equation (1) applications. In such applications, our device would produce hyperpolarized 129 Xe for dissolution into a liquid through use of a microfluidic gas-liquid mixer 29 . The NMR-encoded 129 Xe might be removed from the liquid through a microfluidic analogue of a superhydrophobic thin film 30 and then detected in situ with our integrated magnetometer, enabling extremely high chemical sensitivity, or detected ex situ with a physically separate chipscale atomic magnetometer.…”

Section: Discussionmentioning

confidence: 99%

Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip

et al. 2014

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Optically hyperpolarized 129 Xe gas has become a powerful contrast agent in nuclear magnetic resonance (NMR) spectroscopy and imaging, with applications ranging from studies of the human lung to the targeted detection of biomolecules. Equally attractive is its potential use to enhance the sensitivity of microfluidic NMR experiments, in which small sample volumes yield poor sensitivity. Unfortunately, most 129 Xe polarization systems are large and non-portable. Here we present a microfabricated chip that optically polarizes 129 Xe gas. We have achieved 129 Xe polarizations 40.5% at flow rates of several microlitres per second, compatible with typical microfluidic applications. We employ in situ optical magnetometry to sensitively detect and characterize the 129 Xe polarization at magnetic fields of 1 mT. We construct the device using standard microfabrication techniques, which will facilitate its integration with existing microfluidic platforms. This device may enable the implementation of highly sensitive 129 Xe NMR in compact, low-cost, portable devices.

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Porous Microfluidic Devices – Fabrication and Applications

Cited by 22 publications

References 16 publications

A microfluidic chip for permeability assays of endothelial monolayer

A microfluidic chip for permeability assays of endothelial monolayer

A microgrooved membrane based gas–liquid contactor

Optical hyperpolarization and NMR detection of 129Xe on a microfluidic chip

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