Porous magnesium loaded with gentamicin sulphate and in vitro release behavior

Li, Qiuyan; Jiang, Guofeng; Wang, Dong; Wang, Huang; Ding, Liang; He, Guo

doi:10.1016/j.msec.2016.06.074

Cited by 13 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The volume of the medium was maintained at a constant volume by adding phosphate buffer solution equal to the amount withdrawn for analysis. The concentrations of drug were measured using the quantified method described in the reference [14]. The percentage of drug release was calculated by dividing the amount of drug in the release medium by the total gentamicin introduced to the CS-GT film.…”

Section: Assessment Of Drug Release In Vitromentioning

confidence: 99%

“…In this paper, we use the chemical cross-linking method to add gentamicin, a broad-spectrum aminoglycoside antibiotic which is effective against most species of both gram-positive and gram-negative aerobic bacteria through inhibits the bacteria protein synthesis [12][13][14], to the chitosan to prepare a novel gentamicin-containing antibacterial chitosan film (CS-GT). The gentamicin was grafted onto the surface of chitosan film via citric acid as a transitional object, 1-Ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as the cross-linker.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility

Yang

et al. 2017

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Gentamicin modified chitosan film (CS-GT) was produced using a three-step procedure comprising: (i) the chitosan solution was air-dried to form a chitosan (CS) film, (ii) using citric acid to generate the amide and carboxyl groups on the surface of CS, (iii) the CS with surface carboxyl groups was modified by grafting of gentamicin. After modification, this CS-GT film has excellent hydrophilicity and biocompatibility. It is very evident that the gentamicin grafting treatment significantly improves the antibacterial properties of the CS film. Our preliminary results suggest that this novel gentamicin modified chitosan film, which can be prepared in large quantities and at low cost, should have potential application in biomedical applications.

show abstract

Section: Assessment Of Drug Release In Vitromentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility

Yang

et al. 2017

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

show abstract

“…Any such elongation would also make feasible the potential surgical delivery of porous degradable structures. [76] …”

Section: Discussionmentioning

confidence: 99%

Current Status and Recent Developments in Porous Magnesium Fabrication

et al. 2017

View full text Add to dashboard Cite

A significant number of studies have been dedicated to the fabrication and properties of metallic foams. The most recent research is focused on metals with low weight and good mechanical properties, such as titanium, aluminum, and magnesium. Whereas the first two are already fairly well studied and already find application in industry, magnesium currently remains at the research stage. The present review covers the studies conducted on fabrication techniques, surface modifications, and properties of porous structures made of magnesium and its alloys.

show abstract

“…Zhao et al [58] evaluated the corrosion resistance and drug release profile of gentamicin-loaded polyelectrolyte multilayers (PEMs) on magnesium alloys and concentrated on the effects of heat treatment for the first time. Positively charged allylamine hydrochloride (PAH) [59] and negatively charged polyacrylic acid (PAA) [60] were selected to form polyelectrolytes onto AZ31 magnesium alloys in their study, and gentamicin sulfate (GS) was incorporated into the PEMs to improve the antibacterial properties of the substrate [61,62]. Crosslinking between the polyelectrolytes was achieved by heat treatment to enhance the binding between GS and other charged assembly units.…”

Section: Polymer-based Coatings Combined With Antibioticsmentioning

confidence: 99%

Advances in Antibacterial Functionalized Coatings on Mg and Its Alloys for Medical Use—A Review

Zhang

Liu

et al. 2020

Coatings

View full text Add to dashboard Cite

As a revolutionary implant material, magnesium and its alloys have many exciting performances, such as biodegradability, mechanical compatibility, and excellent biosecurity. However, the rapid and uncontrollable degradation rate of magnesium greatly hampers its clinical use. Many efforts have been taken to enhance the corrosion resistance of magnesium. However, it must be noted that improving the corrosion resistance of magnesium will lead to the compromise of its antibacterial abilities, which are attribute and proportional to the alkaline pH during its degradation. Providing antibacterial functionalized coating is one of the best methods for balancing the degradation rate and the antibacterial ability of magnesium. Antibacterial functionalized magnesium is especially well-suited for patients with diabetes and infected wounds. Considering the extremely complex biological environment in the human body and the demands of enhancing corrosion resistance, biocompatibility, osteogenesis, and antibacterial ability, composite coatings with combined properties of different materials may be promising. The aim of this review isto collect and compare recent studies on antibacterial functionalized coatings on magnesium and its alloys. The clinical applications of antibacterial functionalized coatings and their material characteristics, antibacterial abilities, in vitro cytocompatibility, and corrosion resistance are also discussed in detail.

show abstract

Porous magnesium loaded with gentamicin sulphate and in vitro release behavior

Cited by 13 publications

References 40 publications

Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility

Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility

Current Status and Recent Developments in Porous Magnesium Fabrication

Advances in Antibacterial Functionalized Coatings on Mg and Its Alloys for Medical Use—A Review

Contact Info

Product

Resources

About