Porous Inorganic Materials for Bioanalysis and Diagnostic Applications

Abstract

Porous inorganic materials play an important role in adsorbing targeted analytes and supporting efficient reactions in analytical science. The detection performance relies on the structural properties of porous materials, considering the tunable pore size, shape, connectivity, etc. Herein, we first clarify the enhancement mechanisms of porous materials for bioanalysis, concerning the detection sensitivity and selectivity. The diagnostic applications of porous material-assisted platforms by coupling with various analytical techniques, including electrochemical sensing, optical spectrometry, and mass spectrometry, etc., are then reviewed. We foresee that advanced porous materials will bring far-reaching implications in bioanalysis toward real-case applications, especially as diagnostic assays in clinical settings.

Adenine‐Functionalized Dendritic Fibrous Nanosilica as Bifunctional Catalyst for CO2 Fixation into Cyclic Carbonate

“…The development of efficient, robust, and less toxic porous materials has been gaining tremendous attention for sustainable and effective utilization of CO 2 into value‐added fuels and chemicals. Silica‐based porous materials, such as MCM‐41, SBA‐15, and mesoporous silica, have set up important space in many emerging fields, including sensing, separation, catalysis, energy harvesting and storage, CO 2 capture and cycloaddition, drug delivery, biomedical field, water and air treatment, and coating [24–28] . The usage of silica‐based materials is mainly due to their porous structure and high surface area, which allow guest molecules to disperse or bind onto their internal pore [5] .…”

“…Silica-based porous materials, such as MCM-41, SBA-15, and mesoporous silica, have set up important space in many emerging fields, including sensing, separation, catalysis, energy harvesting and storage, CO 2 capture and cycloaddition, drug delivery, biomedical field, water and air treatment, and coating. [24][25][26][27][28] The usage of silica-based materials is mainly due to their porous structure and high surface area, which allow guest molecules to disperse or bind onto their internal pore. [5] Polshettiwar et al synthesized a low-density three-dimensional dendritic fibrous nanosilica (DFNS) with superior structural features.…”

Porous organic–inorganic hybrid materials for catalysis, energy and environmental applications

“…3 However, the application of this fast-growing research field has been considerably extended in areas ranging from medical diagnosis to energy storage. 4,5 Based on the dimensions of their pores, porous materials are classified by IUPAC as: microporous: pore size below 2.0 nm, mesoporous: between 2.0 to 50 nm and macroporous: pore dimensions above 50 nm. The performance of a porous material towards a particular application depends directly on its shape, size and void space.…”

Advances on Porous Nanomaterials for Biomedical Application (Drug Delivery, Sensing, and Tissue Engineering)

“…In this direction, a review from Liu et al provided a complete overview of the inorganic porous nanomaterials and their use in bioanalysis and diagnostic. 8 They identified that various porous nanomaterials have been used in this field for three main purposes: (1) sample enrichment, (2) enzyme/ catalyst confinement, and (3) signal amplification. The review then covered various types of electrochemical-, optical-, and mass-spectroscopy-based sensors that have utilized porous materials for one of the three aforementioned purposes.…”

“…In addition to therapeutics delivery, porous nanomaterials have gained tremendous attention for use in diagnostics and bioanalysis. In this direction, a review from Liu et al provided a complete overview of the inorganic porous nanomaterials and their use in bioanalysis and diagnostic . They identified that various porous nanomaterials have been used in this field for three main purposes: (1) sample enrichment, (2) enzyme/catalyst confinement, and (3) signal amplification.…”