Porous High-Density Polyethylene Implants in Auricular Reconstruction

Williams, James D.; Romo, Thomas; Sclafani, Anthony P.; Cho, Hyun

doi:10.1001/archotol.1997.01900060020003

Cited by 73 publications

(45 citation statements)

References 12 publications

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“…The homopolymers polyethylene and polyvinyl alcohol (PVA), from which the copolymer EVOH is derived, have a long history as implant materials. Polyethylene is used in numerous implant applications, including surgical spinal cable [7], auricular reconstruction [9,25], prostheses for spinal disk replacement [4,12], and joint implants for the acetabular, patellar, and tibial surfaces [21,26,27]. In addition to these wellestablished uses, polyethylene is a reference standard often employed as a negative polymer control during biocompatibility testing [24].…”

Section: Discussionmentioning

confidence: 99%

Lower esophageal sphincter injection of a biocompatible polymer

Peters

Silverman²,

Stein³

2003

Surg Endosc

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Section: Discussionmentioning

confidence: 99%

Lower esophageal sphincter injection of a biocompatible polymer

Peters

Silverman²,

Stein³

2003

Surg Endosc

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“…133,134 Alternative approaches using alloplastic implants, such as silicon or high-density polyethylene (HDPE), have been introduced and approved by the Food and Drug Administration (FDA) for clinical applications. 135,136 Although alloplastic implants are biologically stable and provide several advantages, including no donor site morbidity and long-term structural integrity when compared to autologous costal cartilage tissue, problems with vascularization and tissue integration at the interface between the alloplastic implant and the overlying skin often lead to infection, inflammation, and overlying skin necrosis, resulting in implant failure. 137 Tissue engineering strategy has been considered as an alternative means to reconstruct auricular defects.…”

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Lee

Yoo

Atala³

2014

Polymer Korea

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Tissue engineering and regenerative medicine strategies could offer new hope for patients with serious tissue injuries or end-stage organ failure. Scientists are now applying the principles of cell transplantation, material science, and engineering to create biological substitutes that can restore and maintain normal function in diseased or injured tissues/ organs. Specifically, creation of engineered tissue construct requires a polymeric biomaterial scaffold that serves as a cell carrier, which would provide structural support until native tissue forms in vivo. Even though the requirements for scaffolds may be different depending on the target applications, a general function of scaffolds that need to be fulfilled is biodegradability, biological and mechanical properties, and temporal structural integrity. The scaffold's internal architecture should also enhance the permeability of nutrients and neovascularization. In addition, the stem cell field is advancing, and new discoveries in tissue engineering and regenerative medicine will lead to new therapeutic strategies. Although use of stem cells is still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This review discusses these tissue engineering and regenerative medicine strategies for various tissues and organs.

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“…Most current therapies to repair damaged cartilage have limitations. The advantages of alloplastic implants, such as those composed of silicone [1,2] or polypropylene [3,4], include widespread availability, consistent predetermined shape, and short operation time. However, risks of infection, extrusion, biocompatibility, and uncertain long-term durability are major concerns.…”

Section: Introductionmentioning

confidence: 99%