Porous Cu_xCo_yS Supraparticles for In Vivo Telomerase Imaging and Reactive Oxygen Species Generation

Abstract

In this study, we successfully synthesized CuxCoyS supraparticles (SPs) on the nanoscale featuring multiple pores inside and strong absorption from 400 to 900 nm. Porous CuxCoyS SPs produced the highest reactive oxygen species (ROS) yield (1.39) when illuminated with near‐infrared (NIR) light. Furthermore, we demonstrated that CuxCoyS SPs could be used to identify cancer cells through intracellular telomerase‐responsive fluorescence (FL) imaging in living cells. Because the CuxCoyS SPs were associated with telomerase‐responsive bioimaging and high ROS production, they can be efficiently used in the diagnosis and therapy of tumors with high selectivity and excellent therapeutic effects in vivo. This study provides a new vision for the creation of multifunctional SPs, which can be used as cellular sensors and control tools for pathologies across a broad range of biological systems.

Selective conversion of syngas to propane over ZnCrO -SSZ-39 OX-ZEO catalysts

“…We also considered the intimacy between metal oxides and zeolites, as it has been previously demonstrated to be another vital factor in syngas conversion [9,10,17,[23][24][25] . By simply changing the granule size of the metal oxide and zeolite components, the catalytic performance changes.…”

Enhancing Antitumor Efficacy by Simultaneous ATP‐Responsive Chemodrug Release and Cancer Cell Sensitization Based on a Smart Nanoagent

“…To verify the potential of the NCs for monitoring intracellular ATP level, HepG2 cells were cultured with the NCs in the presence of apyrase, which can induce the reduction of intracellular ATP contents by catalyzing the hydrolysis of ATP. [22] Cellular uptake study indicated that cellular NCs contents were not obviously affected with apyrase treatment ( Figure S11, Supporting Information). Significantly, cellular fluorescence was diminished in cells treated with apyrase compared to that without apyrase treatment (Figure 2d), suggesting the specific imaging of intracellular ATP level.…”

Iron‐Mediated Oxidative C–H Alkylation of S,S‐Functionalized Internal Olefins via C(sp2)–H/C(sp3)–H Cross‐Coupling

“…Unexpectedly, ethylbenzene could demonstrate a moderate reactivity to form the relatively sterically hindered benzylation products 7w and 7x (55–59%). These results have supplemented the previous work on C–H benzylation of electron‐rich arenes and activated olefins through iron‐catalyzed oxidative C–H/C–H cross‐coupling.…”