Porous calcium polyphosphate scaffolds for bone substitute applications — in vitro characterization

Pilliar, Robert M.; Filiaggi, Mark; Wells, Jonathon; Grynpas, Marc D.; Kandel, Rita A.

doi:10.1016/s0142-9612(00)00261-1

Cited by 338 publications

(261 citation statements)

References 41 publications

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“…Enhancement of the interface between the implants and cells has been attempted by creating open pores on the implant surface [38], making fiber metal composites [39], and treating the surface of the implants with calcium phosphates [40][41] by varying thermal conditions [42]. The interface was evaluated by cell adhesion, proliferation, and differentiation [35,43], as well as by cell morphology and cytoskeleton by scanning or confocal microscopy by synthesis of the proteins of the extracellular matrix and proteoglycans [36].…”

Section: Discussionmentioning

confidence: 99%

Porous composite prosthetic pylon for integration with skin and bone

Pitkin¹,

Raykhtsaum²,

Pilling³

et al. 2007

JRRD

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Abstract-This article presents results of the further development and testing of the "skin and bone integrated pylon" (SBIP-1) for percutaneous (through skin) connection of the residual bone with an external limb prosthesis. We investigated a composite structure (called the SBIP-2) made of titanium particles and fine wires using mathematical modeling and mechanical testing. Results showed that the strength of the pylon was comparable with that of anatomical bone. In vitro and in vivo animal studies on 30 rats showed that the reinforcement of the composite pylon did not compromise its previously shown capacity for inviting skin and bone cell ingrowth through the device. These findings provide evidence for the safe and reliable long-term percutaneous transfer of vital and therapeutic substances, signals, and necessary forces and moments from a prosthetic device to the body.

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Section: Discussionmentioning

confidence: 99%

Porous composite prosthetic pylon for integration with skin and bone

Pitkin¹,

Raykhtsaum²,

Pilling³

et al. 2007

JRRD

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“…The porosity must be interconnected to allow the ingrowth of cells, vascularization and diffusion of nutrients. Typical porosities for HA scaffolds described in the literature range from 35 % [27,28] to 75 % [28] with pore sizes between 50 µm [25] and 400 µm [28]. A preponderance of pores this large can make the implant material rather weak.…”

Section: Freeze Castingmentioning

confidence: 99%

Porous ceramic scaffolds with complex architectures

Munch

Franco

Deville

et al. 2008

JOM

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This work compares two novel techniques for the fabrication of ceramic scaffolds for bone tissue engineering with complex porosity: robocasting and freeze casting. Both techniques are based on the preparation of concentrated ceramic suspensions with suitable properties for the process. In robocasting, the computer-guided deposition of the suspensions is used to build porous materials with designed three dimensional (3-D) geometries and microstructures. Freeze casting uses ice crystals as a template to form porous lamellar ceramic materials. Preliminary results on the compressive strengths of the materials are also reported.

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“…Porous CPP substrates were produced by sintering calcium polyphosphate (CPP) glass powders as described previously [18,41]. Briefly, CPP powder ([Ca(P03)2],,) was formed by calcining calcium phosphate monobasic monohydrate crystals (Ca(H2P0,), .…”

Section: Calcium Polyphospliute Substratesmentioning

confidence: 99%

The use of specific chondrocyte populations to modulate the properties of tissue‐engineered cartilage

Waldman

Grynpas

Pilliar

et al. 2003

Journal Orthopaedic Research

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Tissue engineering of articular cartilage is a promising alternative to the conventional approaches for cartilage repair. However, recent attempts to develop articular cartilage in vitro have proven to be difficult. The tissue formed in vitro may not accumulate enough extracellular matrix, and the resulting mechanical properties are only a fraction of the native tissue. We investigated whether using specific populations of chondrocytes would improve the properties of the cartilaginous tissue that was generated in vitro. Fullthickness (FT), mid-and-deep zone (MD), and deep-zone (DEEP) chondrocytes were isolated, placed on the surface of porous ceramic substrates and maintained in culture for eight weeks.

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Porous calcium polyphosphate scaffolds for bone substitute applications — in vitro characterization

Cited by 338 publications

References 41 publications

Porous composite prosthetic pylon for integration with skin and bone

Porous composite prosthetic pylon for integration with skin and bone

Porous ceramic scaffolds with complex architectures

The use of specific chondrocyte populations to modulate the properties of tissue‐engineered cartilage

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