Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method

Varma, H. K.

doi:10.1016/s0142-9612(98)00243-9

Cited by 136 publications

(102 citation statements)

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“…When compared with standard HA however, the inorganic phase peaks in the mineralized product were wider with several overlapping peaks. This indicates that the crystallinity of the inorganic phase was very low with small crystallite size, closely resembling natural bone tissue [12].…”

Section: Bio-mineralization Of Mc3t3-e1 Cell-seeded Bg-col1-ps Composmentioning

confidence: 69%

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Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds

Chao¹,

Wang²,

Chen³

2012

Sci. China Life Sci.

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Section: Bio-mineralization Of Mc3t3-e1 Cell-seeded Bg-col1-ps Composmentioning

confidence: 69%

“…Naturally-derived collagen has the advantage of permitting specific cellular interactions, owing to its hydrophilic property [11]. Phosphatidylserine (PS) is an important compo-nent of cell velum lipid and plays a key role in tissue development, repair and function [12].…”

mentioning

confidence: 99%

Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds

Chao¹,

Wang²,

Chen³

2012

Sci. China Life Sci.

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“…Besides, the peaks of 211, 112 and 300 overlapped with each other without division, suggesting that the crystallinity of the apatite crystals was very low. Compared with JCPDS standard card of HA, the peaks of the apatite crystals in the mineralized samples became wider, which indicated that the crystallite size was tiny and the crystallinity was very low, closely resembling that of the natural bone tissue [20,21]. Moreover, the diffraction peak at 2!…”

Section: Characterization Of Composite Membranesmentioning

confidence: 94%

Biomimetic synthesis of poly(lactic-co-glycolic acid)/multi-walled carbon nanotubes/apatite composite membranes

Zhang¹

2012

Express Polym. Lett.

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Abstract. Bioactive guided tissue regeneration (GTR) membrane has had some success for periodontal therapy. In this study, poly(lactic-co-glycolic acid) (PLGA)/multi-walled carbon nanotubes (MWNTs) composite membranes were incubated in three supersaturated calcification solutions (SCS) of different pH values for 21 days to prepare a PLGA/ MWNTs/apatite composite. Scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), energy dispersive spectroscopy (EDS), water contact angle measurement and mechanical testing were used for characterization. It was found that after 21 days incubation, apatite with low crystallite size and crystallinity was formed on the PLGA/MWNTs composite membranes. The Ca-poor carbapatite was similar in morphology and composition to that of natural bone. The size and shape of the apatite crystals immersed in three SCS were different from each other. The hydrophilicity and mechanical properties of the PLGA/MWNTs composite membranes were significantly enhanced after mineralization. This indicated that biomimetic mineralization may be an effective method to improve the biocompatibility and bone inductivity of certain materials. The PLGA/MWNTs/apatite composites may be potentially useful in GTR applications, particularly as GTR membranes for periodontal tissue regeneration.

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“…The XPS data proved the formation of HA on the surface of chitosan-grafted PLLA fibers, indicating that the PLLA-CS membrane has bioactivity. The formation of HA on the surface of a biomaterial is important for the materials to bond with the surrounding tissue [31,32] after implantation. The biomineralization on PLLA-CS membrane is relevant to the special ionic groups and polar groups of chitosan.…”

Section: Characterization Of Plla-cs Membranementioning

confidence: 99%

Biodegradable electrospun PLLA/chitosan membrane as guided tissue regeneration membrane for treating periodontitis

et al. 2013

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This paper explores the application potential of a biodegradable PLLA/chitosan electrospun composite membrane for guided periodontal tissue regeneration which in addition serves as a fibroblast barrier. Electrospinning was applied to fabricate the PLLA membrane and aminolysis method was applied to graft chitosan on its surface. The morphology of the PLLA/chitosan membrane was observed by SEM. The surface chemical composition was analyzed by XPS. The appearance of N 1s peak in XPS demonstrated the successful grafting of chitosan on the PLLA electrospin membrane. After the modification, the water contact angle decreased from 136.9 ± 2.18°to 117.0 ± 2.10°, representing an improved hydrophilicity of the membrane. The bioactivity of the membrane was analyzed by XPS after soaking in SBF. The deposits had a Ca/P ratio of 1.6, indicating the hydroxyapatite formation on PLLA/chitosan membrane. The degradation rate was determined by measuring mass loss after immersion in PBS at different time periods. Compared to pure PLLA electrospun membrane which was almost nondegradable, the degradation rate of PLLA/chitosan composite membrane was up to 20 % in 6 weeks while maintaining its basic architecture to keep supporting the regenerated tissue. Live-dead cell staining of MC3T3 E1 cells cultured on the surface of the membrane showed a good biocompatibility of the PLLA/chitosan membrane. Furthermore, fibroblast cell line NIH 3T3 was cultured on surface of the membrane for the evaluation of cell penetration. The result demonstrated that the membrane worked as a fibroblast barrier to minimize the unfavorable effect of fibroblasts on periodontal tissue regeneration. Therefore, this electrospun PLLA/chitosan composite membrane has more potential for clinical application compared to old generation regeneration membrane with both suitable degradation rate and non-fibroblast penetration property.

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Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method

Cited by 136 publications

References 0 publications

Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds

Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds

Biomimetic synthesis of poly(lactic-co-glycolic acid)/multi-walled carbon nanotubes/apatite composite membranes

Biodegradable electrospun PLLA/chitosan membrane as guided tissue regeneration membrane for treating periodontitis

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