Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization

Abstract

Abstract.A new bioactive glass-based scaffold was developed for local delivery of drugs in case of osteomyelitis. Bioactive glass having a new composition was prepared and converted into porous scaffold. The bioactivity of the resulting scaffold was examined by in vitro acellular method. The scaffolds were loaded with two different drugs, an antibacterial or antifungal drug. The effects of the size of the scaffold, drug concentration, and dissolution medium on drug release were studied. The scaffolds were further coated with a degradable natural polymer, chitosan, to further control the drug release. Both the glass and scaffold were bioactive. The scaffolds released both the drugs for 6 weeks, in vitro. The results indicated that the bigger the size and the higher the drug concentration, the better was the release profile. The scaffolds appeared to be suitable for local delivery of the drugs in cases of osteomyelitis.

Effect of the composition of hydroxyapatite/bioactive glass nanocomposite foams on their bioactivity and mechanical properties

“…These P-O bands in the samples with 25, 50, and 75 wt.% BG due to the presence of HA, are more specific, but in the sample with 100 wt.% BG a broad band at 570-602 cm À1 was present after soaking in SBF for 28 days, implying the formation of an amorphous or thin calcium phosphate layer. Bands for the phosphate groups [39,40]. The carbonate peaks revealed that the HA contained some CO 3 2À groups in PO 4 3À sites of apatite lattice.…”

“…The FTIR data in Fig. 9 shows that in addition to the absorbances for bone-like apatite (bands of phosphate and carbonate groups), strong bands due to silicate groups of BG (523 cm À1 : Si-O-Si bending n 4 ; 743 and 844 cm À1 : Si-O symmetric stretching n 3 ) are present for the foams with different compositions [39,41,42]. Fig.…”

Development of nanoantibiotic delivery system using cockle shell-derived aragonite nanoparticles for treatment of osteomyelitis

“…The spectrum was recorded at ambient temperature over a wavenumber range of 4,000-400 cm −1 at 2 cm −1 resolution 18 by averaging 64 scans.…”

Synthesis and Characterization of Hydroxyapatite/Bioactive Glass Nanocomposite Foam and Fluorapatite/Bioactive Glass Nanocomposite Foam by Gel Casting Method as Cell Scaffold for Bone Tissue

“…The peak observed in the range of 3420-3430cm -1 is associated with vibrations of absorbed water bond [7]. Results of FTIR analysis demonstrated that strong bonds of bioactive silicate glass group (795-815cm -1 : Si-O symmetric stretching v3) are observed in the foams with both composites, in addition to phosphate and carbonate groups of bone-like apatite [55][56][57][58].…”