Porous Au@Pt Nanoparticles: Therapeutic Platform for Tumor Chemo-Photothermal Co-Therapy and Alleviating Doxorubicin-Induced Oxidative Damage

Yang, Qian; Peng, Jinrong; Xiao, Yao; Li, Wenting; Tan, Liwei; Xu, Xianglan; Zhang, Qian

doi:10.1021/acsami.7b14705

Cited by 113 publications

(98 citation statements)

References 48 publications

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“…Sensing LSPR shift AuAg [163] Surface-enhanced Raman scattering (SERS) AuAg [76] AuAg [166] GMR sensor; competition assay FeCo [112,113,187] Magnetic capture FePt [171] Magnetically-enhanced colorimetric biosensing PtCo [117] QCM with magnetically controlled permeability AuCo [80] Electrochemical biosensor PtPd [96] Imaging An imaging probe screening with dual energy mammography or computed tomography AuAg [71] The optical absorption cross sections AuAg [72] MRI contrast agent (no imaging) FePt [103] MRI in vitro FePt [105] FeNi [115] PtCo [40] MRI in vivo AuCu [84] FeCo [110] FePt [177] Dual modal CT/MRI molecular imaging in vitro and in vivo FePt [132] MRI and near-infrared agents FeCo [111] Multimodal imaging − Computed tomography (CT), − Magnetic resonance imaging (MRI), − Photoacoustic (PA) imaging, − High-order multiphoton luminescence (HOMPL) microscopy FePt [102] in vivo Multimodal SERS-MRI-CT imaging AuFe [79] in vivo NIR thermal imaging and photoacoustic imaging AuPt [95] Thermal treatment in vitro hyperthermia FePt [109] Photothermal FePt [104] Hyperthermia CuNi [119,188] Tumor chemo-photothermal therapy AuPt [95]…”

Section: Application Principle Materials Referencementioning

confidence: 99%

“…Drug carrier by pore structure and release by photothermal conversion FePt [109] Gene delivery by functionalized surface AuNi [83] Drug delivery by pore structure AuPt [95] Photothermally enhanced photodynamic therapy PdAg [118,189] In addition to photothermal treatments, another class of hyperthermia treatment is magnetic hyperthermia-a therapy that depends on magnetic nanomaterials that can be selectively positioned near target cells and generate localized heat when exposed to an alternating external magnetic field.…”

Section: Drug Deliverymentioning

confidence: 99%

“…In addition to exploring the drug-delivery efficacy, recent nanoparticle-based research has also focused on developing additional capabilities that are beneficial to the patients receiving the treatments, such as reducing the systemic toxicity. Yang et al, for example, synthesized multifunctional Au@Pt nanoparticles that allow for the loading of the anticancer drug, doxorubicin (DOX) [95]. The DOX-loaded nanoparticles serve as a chemo-photothermal combination therapy platform with oxidative stress reduction ( Figure 12).…”

Section: Drug Deliverymentioning

confidence: 99%

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Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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Metal nanoparticles are extensively studied due to their unique chemical and physical properties, which differ from the properties of their respective bulk materials. Likewise, the properties of heterogeneous bimetallic structures are far more attractive than those of single-component nanoparticles. For example, the incorporation of a second metal into a nanoparticle structure influences and can potentially enhance the optical/plasmonic and magnetic properties of the material. This review focuses on the enhanced optical/plasmonic and magnetic properties offered by bimetallic nanoparticles and their corresponding impact on biological applications. In this review, we summarize the predominant structures of bimetallic nanoparticles, outline their synthesis methods, and highlight their use in biological applications, both diagnostic and therapeutic, which are dictated by their various optical/plasmonic and magnetic properties.

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Section: Application Principle Materials Referencementioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

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Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

et al. 2018

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“…In particular, exosomes are being investigated as nanoparticle carriers for therapeutics delivery [14-17]. Currently, the main methods to deliver therapeutics include liposomal, polymeric and other nanoparticles [18-22]. However, these nanoparticles have limitations due to issues such as immunogenicity, stability, and long-term safety.…”

Section: Introductionmentioning

confidence: 99%

Development and MPI tracking of novel hypoxia-targeted theranostic exosomes

et al. 2018

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Treating the hypoxic region of the tumor remains a significant challenge. The goals of this study are to develop an exosome platform that can target regions of tumor hypoxia and that can be monitored in vivo using magnetic particle imaging (MPI). Four types of exosomes (generated under hypoxic or normoxic conditions, and with or without exposure to X-ray radiation) were isolated from MDA-MB-231 human breast cancer cells. Exosomes were labeled by DiO, a fluorescent lipophilic tracer, to quantify their uptake by hypoxic cancer cells. Subsequently, the exosomes were modified to carry SPIO (superparamagnetic iron oxide) nanoparticles and Olaparib (PARP inhibitor). FACS and fluorescence microscopy showed that hypoxic cells preferentially take up exosomes released by hypoxic cells, compared with other exosome formulations. In addition, the distribution of SPIO-labeled exosomes was successively imaged in vivo using MPI. Finally, the therapeutic efficacy of Olaparib-loaded exosomes was demonstrated by increased apoptosis and slower tumor growth in vivo. Our novel theranostic platform could be used as an effective strategy to monitor exosomes in vivo and deliver therapeutics to hypoxic tumors.

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“…Due to the unique optical and physicochemical properties, gold nanoparticles have been well established as excellent candidates for biomedical applications such as drug/gene delivery, biological imaging, and photothermal cancer treatment . Among various well‐developed gold nanoparticles, gold nanorods (Au NRs) are in particular promising and have been widely utilized because of their easy synthesis and tunable maxima absorption in the near‐infrared (NIR) region .…”

Section: Introductionmentioning

confidence: 99%

Effects of Cetyltrimethylammonium Bromide on the Toxicity of Gold Nanorods Both In Vitro and In Vivo: Molecular Origin of Cytotoxicity and Inflammation

et al. 2020

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The safety issues and immunological effects of nanosized materials have drawn considerable attention. Gold nanorods (Au NRs) have promising applications in biomedical diagnosis and therapy, but their biosafety and the mechanism underlying in vivo toxicity still remain to be explored. In this study, cetyltrimethylammonium bromide (CTAB) capped Au NRs and PEG modified Au NRs are both prepared, the cytotoxicity evaluation indicates that CTAB‐Au NRs of different ratios all exhibit cytotoxicity while PEG‐Au NRs show improved biocompatibility. Furthermore, it is investigated how the surface characteristics influence toxical effects of Au NRs both in vitro and in vivo. It is found that CTAB‐Au NRs can induce acute cell necrosis, which results in the leakage of damage associated molecular patterns (DAMPs) such as mitochondrial DNA (mtDNA), subsequently triggering pulmonary inflammation. It is also revealed that the inflammation caused by CTAB‐Au NRs is probably mediated by the stimulator of interferon genes (STINGs) signaling pathway. This study explores the cytotoxicity and inflammatory toxicity of CTAB‐Au NRs, and how the surface modification affects the toxicity. The molecular pathways for the induction of pulmonary inflammation in vivo are further characterized. These findings might be of importance for designing safer and better gold‐based nanomaterials in the future.

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Porous Au@Pt Nanoparticles: Therapeutic Platform for Tumor Chemo-Photothermal Co-Therapy and Alleviating Doxorubicin-Induced Oxidative Damage

Cited by 113 publications

References 48 publications

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

Bimetallic Nanoparticles: Enhanced Magnetic and Optical Properties for Emerging Biological Applications

Development and MPI tracking of novel hypoxia-targeted theranostic exosomes

Effects of Cetyltrimethylammonium Bromide on the Toxicity of Gold Nanorods Both In Vitro and In Vivo: Molecular Origin of Cytotoxicity and Inflammation

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