Porous antimicrobial crosslinked film of hydroxypropyl methylcellulose/carboxymethyl starch incorporating gallic acid for wound dressing application

Pitpisutkul, Vipawan; Prachayawarakorn, Jutarat

doi:10.1016/j.ijbiomac.2023.128231

Cited by 5 publications

(1 citation statement)

References 48 publications

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“…Wound dressing/healing PCL/chitosan-carrageenan hydrogel [392] Methyl cellulose [393] Chitosan-PVA hydrogel [394] Hydroxypropyl methylcellulose/carboxymethyl starch [395] Sodium alginate-grafted poly(β-carboxyethyl acrylate-co-acrylamide) hydrogel [396] Chitosan+hyaluronic acid hydrogels [397] Biosensors Silk [398,399] Nanocellulose [400] Chitosan films [401] Poly (vanillin-co-chitosan) [402] Drug delivery…”

Section: Applicationmentioning

confidence: 99%

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Kuperkar,

Atanase,

Bahadur

et al. 2024

Polymers

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Degradable polymers (both biomacromolecules and several synthetic polymers) for biomedical applications have been promising very much in the recent past due to their low cost, biocompatibility, flexibility, and minimal side effects. Here, we present an overview with updated information on natural and synthetic degradable polymers where a brief account on different polysaccharides, proteins, and synthetic polymers viz. polyesters/polyamino acids/polyanhydrides/polyphosphazenes/polyurethanes relevant to biomedical applications has been provided. The various approaches for the transformation of these polymers by physical/chemical means viz. cross-linking, as polyblends, nanocomposites/hybrid composites, interpenetrating complexes, interpolymer/polyion complexes, functionalization, polymer conjugates, and block and graft copolymers, are described. The degradation mechanism, drug loading profiles, and toxicological aspects of polymeric nanoparticles formed are also defined. Biomedical applications of these degradable polymer-based biomaterials in and as wound dressing/healing, biosensors, drug delivery systems, tissue engineering, and regenerative medicine, etc., are highlighted. In addition, the use of such nano systems to solve current drug delivery problems is briefly reviewed.

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Section: Applicationmentioning

confidence: 99%

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Kuperkar,

Atanase,

Bahadur

et al. 2024

Polymers

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Controlled curcumin delivery via carboxymethyl starch‐modified gamma alumina nanoparticles in a polyethylene glycol‐based hydrogel

Adeli,

Pourmadadi,

Abdouss

et al. 2024

J of Applied Polymer Sci

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One of the most prevalent cancers affecting women globally is breast cancer. Consequently, the development of cost‐effective and low‐risk treatment options remains a critical pursuit. This study describes the synthesis via water‐in‐oil‐in‐water (W/O/W) of a pH‐responsive nanocarrier for curcumin delivery, a promising anticancer drug. The nanocarrier comprises carboxymethyl starch (CMS), polyethylene glycol (PEG), and gamma alumina (γ‐Al2O3) nanoparticles. The molecular interactions between the nanocomposite components, its crystalline structure, surface morphology, size distribution, and surface charge were assessed via Fourier‐transformed infrared (FTIR) spectroscopy, field emission‐scanning electron microscopy (FE‐SEM), x‐ray diffraction (XRD), dynamic light scattering (DLS) and zeta potential, respectively. The nanocarrier showed a size ranging from 150 to 280 nm, zeta potential of +35.4 mV, drug loading of 47% and an encapsulation efficiency of 87%, which are among the maximum values reported to date for curcumin nanocarriers. A gradual drug release was observed, with 51% and 90% released after 72 h at pH 7.4 and 5.4, respectively, which corroborates the pH‐sensitivity of the nanocarrier. The cytotoxic effects of the curcumin‐loaded nanocomposite on MCF‐7 breast cancer cells and normal cells were investigated using methylthiazolyldiphenyl‐tetrazolium bromide (MTT) assay and flow cytometry. The results demonstrated that loading curcumin onto the hydrogel significantly enhances its penetration into MCF‐7 cells. Overall, this novel nanocomposite offers a promising approach for curcumin delivery in breast cancer treatment.

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Sustainable materials for novel food packaging based on alginate, methylcellulose and glycerol films functionalized with gallic acid

Leyva-Jiménez,

Abellán-Dieguez,

Oliver-Simancas

et al. 2024

Future Foods

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Porous antimicrobial crosslinked film of hydroxypropyl methylcellulose/carboxymethyl starch incorporating gallic acid for wound dressing application

Cited by 5 publications

References 48 publications

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Degradable Polymeric Bio(nano)materials and Their Biomedical Applications: A Comprehensive Overview and Recent Updates

Controlled curcumin delivery via carboxymethyl starch‐modified gamma alumina nanoparticles in a polyethylene glycol‐based hydrogel

Sustainable materials for novel food packaging based on alginate, methylcellulose and glycerol films functionalized with gallic acid

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