Porokeratotic adnexal ostial naevus: review on the entity and therapeutic approach

Abstract

PAON responded with tazaroten gel, dithranol short-contact treatment and topical photodynamic therapy but laser treatments appear to be more efficient in most patients.

Widespread presentation and spontaneous regression of porokeratotic eccrine ostial and dermal duct nevus

“…Clinical improvement has been most consistently reported with CO 2 laser. 1 , 4 , 11 , 12 , 13 Improvement has also been reported with topical tretinoin (0.5%) cream with urea (10%) 14 and topical photodynamic therapy with aminolevulinic acid. 15 The 2 infants described here had significant spontaneous improvement in clinical appearance despite widespread involvement noted at birth.…”

“… 1 , 2 , 3 Treatment is challenging and options include erbium/carbon dioxide (CO 2 ) lasers, keratolytic agents, and surgical excision. 4 Cases of PEODDN have been reported in association with deafness, polyneuropathy and hyperthyroidism, seizure disorder, and hemiparesis. 4 Most patients are healthy, however, and these associations may be coincidental.…”

“… 4 Cases of PEODDN have been reported in association with deafness, polyneuropathy and hyperthyroidism, seizure disorder, and hemiparesis. 4 Most patients are healthy, however, and these associations may be coincidental. Histologically, the lesions show epidermal hyperplasia with cornoid lamellae located over the eccrine ostia.…”

Porokeratotic eccrine and hair follicle nevus: a report of two cases and review of the literature

“…A comedo-like form (filiform papules with whitish-colored keratin center) has also been noticed. 1 , 4 In congenital lesions, the erythematous component tends to disappear as the patient grows. There are 2 reported cases of systematized PEHFN and 2 cases with localized lesions (cheek and axillae).…”

“…PEHFN responded to CO 2 laser or cryotherapy (extremely painful) and slightly to mometasone, flucinonide, tretinoin or tazarotene. 3 , 4 , 5 Surgical excision is an option for cases with limited body involvement.…”