Porokeratosis of Mibelli: Successful Treatment with Cryosurgery

Abstract

Porokeratosis of Mibelli, a disorder of keratinization, should be treated because of the possibility of development of malignant epithelial tumors on the porokeratotic lesions. Liquid nitrogen cryosurgery is considered to be particularly useful in the treatment of precancerous and benign skin lesions. We aimed to evaluate the efficiency of this method in the treatment of porokeratosis of Mibelli. Eight patients with 20 porokeratotic lesions were treated with spray cryosurgery. Each lesion was frozen for 30 seconds with a spray tip after the keratotic borders were removed conically by sharp dissection. Eighteen of the 20 lesions were healed successfully with slight atrophy in one session. One more session was necessary for the other two lesions. Liquid nitrogen cryosurgery may be considered superior to other destructive methods in the treatment of porokeratosis of Mibelli, with advantages such as simplicity, high cure rates, low cost, short treatment period, and few complications.

Giant verrucous porokeratosis of Mibelli mimicking psoriasis in a patient with psoriasis

“…12 Over the past two decades several cases of PK have been reported during immunodeficiency associated with organ transplantation, hematopoietic malignancies, lymphoma, HIV infection, use of immunosuppressive drugs, or chemotherapy, 17 high doses of corticosteroids, 18 and also occurring during local immunosuppression caused by ultraviolet light. 5 Many therapies have been applied to treat solitary giant PK lesions, including surgical resection, cryosurgery, 19 electrocautery, carbon dioxide laser ablation, 20 keratolytics, oral retinoids, 21 topical 5-fluorouracil, 22 corticosteroids, and, recently, topical imiquimod. 23 Treatment selection depends on lesion size and location, functional and aesthetic requirements, and patient condition.…”

A Case of Inflammatory Disseminated Superficial Porokeratosis in a Colon Cancer Patient

“…Intervention is usually unnecessary. However, if the lesions cause other problems or cosmetically unacceptable, treatment with a topical steroid, topical 5-FU, imiquimod, cryotherapy, a carbon dioxide laser, of a frequency-doubled Q-switched Nd: YAG laser can be considered [12][13][14][15] . Generally, pruritic symptoms will subside spontaneously within several months, but oral antihistamine can be useful if the patient has pruritus.…”

Porokeratosis Mibelli

“…Porokeratozda topikal olarak vitamin D 3 anologları, retinoidler, imikimod, kantaridin, ingenol mebutat, 5-fluorourasil, diklofenak, kortikosteroid, takrolimus, sistemik retinoidler, lazer tedavileri, fotodinamik tedaviler, kriyoterapi, dermabrazyon, total eksizyon gibi geniş tedavi seçenekleri bulunmaktadır. 1,9,10 Bu hastaların tedavisinde güneşten korunma da önemli yer tutmaktadır. 1 PM'de en iyi tedavi seçeneğinin topikal imikimod olduğu belirtilmiştir.…”