Porokeratosis (Mibelli): Treatment with topical 5-fluorouracil

Giant verrucous porokeratosis of Mibelli mimicking psoriasis in a patient with psoriasis

“…12 Over the past two decades several cases of PK have been reported during immunodeficiency associated with organ transplantation, hematopoietic malignancies, lymphoma, HIV infection, use of immunosuppressive drugs, or chemotherapy, 17 high doses of corticosteroids, 18 and also occurring during local immunosuppression caused by ultraviolet light. 5 Many therapies have been applied to treat solitary giant PK lesions, including surgical resection, cryosurgery, 19 electrocautery, carbon dioxide laser ablation, 20 keratolytics, oral retinoids, 21 topical 5-fluorouracil, 22 corticosteroids, and, recently, topical imiquimod. 23 Treatment selection depends on lesion size and location, functional and aesthetic requirements, and patient condition.…”

A case of facial porokeratosis

“…The lesions are inherited as an autosomal dominant condition, but frequently sporadic cases are seen. Many treatment modalities have been tried including keratolytic agents, topical 5‐fluorourasil, 5 topical retinoids, topical imiquimod, 6 cryoterapy, 7 photodynamic therapy, 8 carbon dioxide laser therapy, dermabrasion and excision of the affected area. None of these treatments are universally successful and at present there is no consensus on the optimum approach for this condition.…”

A Case of Inflammatory Disseminated Superficial Porokeratosis in a Colon Cancer Patient

“…Intervention is usually unnecessary. However, if the lesions cause other problems or cosmetically unacceptable, treatment with a topical steroid, topical 5-FU, imiquimod, cryotherapy, a carbon dioxide laser, of a frequency-doubled Q-switched Nd: YAG laser can be considered [12][13][14][15] . Generally, pruritic symptoms will subside spontaneously within several months, but oral antihistamine can be useful if the patient has pruritus.…”