Porogen-induced surface modification of nano-fibrous poly(l-lactic acid) scaffolds for tissue engineering

Liu, Xiaohua; Won, Young Jun; Peter, X.

doi:10.1016/j.biomaterials.2006.03.008

Cited by 134 publications

(92 citation statements)

References 30 publications

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“…A porogen-induced surface modification technique has also been developed in our lab recently [122]. In this technique, the modifying agent is prepared as the porogen.…”

Section: Surface Modificationmentioning

confidence: 99%

“…After phase separation and porogen removal, a nano-fibrous PLLA scaffold was generated with an interconnected spherical pore network. The PLLA nanofibers in this scaffold was modified with a layer of gelatin molecules, which effectively enhanced the cell spreading, proliferation, and ECM secretion [122]. Presumably, the solvent mixture (water/THF) of the PLLA solution ensured the entrapment of the gelatin molecules during the casting and phase-separation because of the solubility of gelatin in water.…”

Section: Surface Modificationmentioning

confidence: 99%

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Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

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Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for transplantation. Biomaterials play a pivotal role as scaffolds to provide three-dimensional templates and synthetic extracellular-matrix environments for tissue regeneration. It is often beneficial for the scaffolds to mimic certain advantageous characteristics of the natural extracellular matrix, or developmental or would healing programs. This article reviews current biomimetic materials approaches in tissue engineering. These include synthesis to achieve certain compositions or properties similar to those of the extracellular matrix, novel processing technologies to achieve structural features mimicking the extracellular matrix on various levels, approaches to emulate cell-extracellular matrix interactions, and biologic delivery strategies to recapitulate a signaling cascade or developmental/would-healing program. The article also provides examples of enhanced cellular/tissue functions and regenerative outcomes, demonstrating the excitement and significance of the biomimetic materials for tissue engineering and regeneration.

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“…A porogen-induced surface modification technique has also been developed in our lab recently [122]. In this technique, the modifying agent is prepared as the porogen.…”

Section: Surface Modificationmentioning

confidence: 99%

Section: Surface Modificationmentioning

confidence: 99%

Biomimetic materials for tissue engineering

Peter

2008

Advanced Drug Delivery Reviews

Self Cite

1,201

819

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“…The surface modifications introduced significantly increased cell adhesion and spreading. In addition, cell proliferation was maintained for more than 2 weeks and the modifications also increased the production of extracellular matrix components [32]. The surface properties of biomaterials can be altered in such a way as to make them more adequate for biomedical applications.…”

Section: Tissue Engineering 230mentioning

confidence: 98%

Bioresorbable Polymers for Tissue Engineering

Santos¹

2010

Tissue Engineering

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Polymeric biomaterials are used as substitutes for damaged tissue and for the stimulation of tissue regeneration. One class of polymeric biomaterials are bioresorbable polymers that degrade both in vitro and in vivo and are used as a temporary support for tissue regeneration. Among the various types of bioresorbable polymers, -hydroxy acids including the different forms of poly(lactic acid) (PLA), such as poly(L-lactic acid), poly(Dlactic acid) and poly(DL-lactic acid), as well as poly(glycolic acid) and polycaprolactone, have been extensively studied. These polymers are well known for their good biocompatibility, with their degradation products being eliminated from the body by metabolic pathways. Many reports have shown that the different PLA-based substrates do not present toxicity since the cells were found to differentiate over the different polymers, as demonstrated by the production of extracellular matrix components by various cell types. In this chapter, we describe the use of -hydroxy acids, highlighting the different forms of PLA scaffolds used as cell culture substrates and their applications in clinical practice. The chapter is divided into (1) Introduction; (2) Bioresorbable devices as cell culture substrates; (3) Cell adhesion to polymer substrates; (4) Tissue engineering and bioresorbable polymers; (5) Cell growth and proliferation on bioresorbable polymers; (6) Bioresorbable polymers for cartilage engineering; (7) Bioresorbable polymers for bone tissue engineering; (8) Bioresorbable polymers for skin tissue engineering, and (9) Conclusion.

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“…Some recent technological advances have facilitated the development of tissue-mimicking designs of biomatrices (Jin (E) Scanning electron microscopic images of rich vascular network (12x), with PDL, alveolar bone (AB), and inferior alveolar artery (IAA), (F) Volkmann's canals (VC; 50x), and (g) alveolar bone and PDL (150x) (Marchesan et al, 2011(Marchesan et al, ). et al, 2003Liu and Ma, 2004;Liu et al, 2006). Cell-secreted biomatrices are also considered a promising platform, since they produce new biologic tissue similar to that of native ECM, ultimately enabling the ex vivo production of tissue-engineered constructs (Iwata et al, 2009).…”

Section: Importance Of Regenerative Approaches and Biomatrices For Pementioning

confidence: 99%

Advanced Biomatrix Designs for Regenerative Therapy of Periodontal Tissues

et al. 2014

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Periodontitis is an inflammatory disease that causes loss of the tooth-supporting apparatus, including periodontal ligament, cementum, and alveolar bone. A broad range of treatment options is currently available to restore the structure and function of the periodontal tissues. A regenerative approach, among others, is now considered the most promising paradigm for this purpose, harnessing the unique properties of stem cells. How to make full use of the body's innate regenerative capacity is thus a key issue. While stem cells and bioactive factors are essential components in the regenerative processes, matrices play pivotal roles in recapitulating stem cell functions and potentiating therapeutic actions of bioactive molecules. Moreover, the positions of appropriate bioactive matrices relative to the injury site may stimulate the innate regenerative stem cell populations, removing the need to deliver cells that have been manipulated outside of the body. In this topical review, we update views on advanced designs of biomatrices-including mimicking of the native extracellular matrix, providing mechanical stimulation, activating cell-driven matrices, and delivering bioactive factors in a controllable manner-which are ultimately useful for the regenerative therapy of periodontal tissues.

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Porogen-induced surface modification of nano-fibrous poly(l-lactic acid) scaffolds for tissue engineering

Cited by 134 publications

References 30 publications

Biomimetic materials for tissue engineering

Biomimetic materials for tissue engineering

Bioresorbable Polymers for Tissue Engineering

Advanced Biomatrix Designs for Regenerative Therapy of Periodontal Tissues

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