Porogen Imprinting Effects

Yoshizako, Kimihiro; Hosoya, Ken; Iwakoshi, Yoshiyuki; Kimata, and Kazuhiro; Tanaka, Nobuo

doi:10.1021/ac970541f

Cited by 88 publications

(48 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An analogy of the structure of atrazine to those of the two solvents leads us to an assumption that the solvents also engaged as templates during the imprinting process and affected the binding ability of resultant polymers. Although the precise mechanism is unknown in our case, solvent effects on the resultant selectivity have been reported by Hosoya et al 9 Although solvents also affected rigidness of the resultant polymers, the influences on 701 ANALYTICAL SCIENCES AUGUST 1998, VOL. 14 and the non-imprinted blank polymers.…”

Section: Solvents Used For Polymer Preparationmentioning

confidence: 51%

Design and Preparation of Molecularly Imprinted Atrazine-Receptor Polymers: Investigation of Functional Monomers and Solvents

1998

View full text Add to dashboard Cite

Molecular imprinting is known as a potential approach to artificial antibodies/receptors and enzyme mimics. A few years ago, we reported on a molecularly imprinted polymer receptor for a triazine herbicide atrazine.1,2 The polymer receptor exhibited a dissociation constant of 10 -5 M and excellent selectivity to atrazine. Two other independent groups also reported on atrazine-imprinted polymers prepared by a similar procedure 3,4 , where radio-ligand assay was demonstrated using atrazine-imprinted polymers as reagents alternative to antibodies. As another application of a molecularly imprinted polymer, solid phase extraction using an atrazine-imprinted polymer has been reported. The imprinted polymer has successfully demonstrated its specificity for extracting a target triazine herbicide from beef liver 5 and from water 6 , showing that the technique is feasible for preparing artificial antibodies/ receptors usable in applications of analytical purpose.Preparation of the atrazine-imprinted polymers 1-4 was carried out according to a protocol well-established by Mosbach, using methacrylic acid as functional monomer, ethylene glycol dimethacrylate as crosslinking agent, and chloroform or dichloromethane as solvent. Although the atrazine-imprinted polymers prepared have shown satisfying performance up to a certain degree, further optimization of the detailed preparation conditions is important to be conducted. Here, we report on the investigation of the preparation of atrazine-imprinted polymer receptor, focusing upon a design of a functional monomer and a selection of solvents used for molecular imprinting. ExperimentalA typical preparation of an atrazine imprinted polymer ( Fig. 1): into 25 ml of chloroform were added atrazine 1 (1.67 mmol), methacrylic acid 2 (6.68 mmol), ethylene glycol dimethacrylate (9.35 g) and 2,2¢-azobis(isobutyronitrile) (120 mg). After being sonicated and sparged with nitrogen gas, the mixture was placed under UV light at 3.5˚C for 12 h. A block polymer obtained was crushed, sieved and packed in a stainless-steel column. The polymer was washed using methanol-acetic acid (7:3, v/v) to remove the template species from the polymer matrix. As functional monomer, 2-(trifluoromethyl)acrylic acid 3 (6.68 mmol) or the glutethimide derivative 4 (1.67 mmol) was used instead of methacrylic acid. As an alternative solvent, 25 ml of toluene, o-xylene, m-xylene, pxylene, mesitylene or 1,4-dioxane was used instead of chloroform, where methacrylic acid was used as the functional monomer. Corresponding non-imprinted polymers were identically prepared in the absence of the template species.Retention of atrazine was measured on the columns filled with the imprinted and non-imprinted polymers, using acetonitrile as the eluent at a flow rate of 1.0 ml 699 ANALYTICAL SCIENCES AUGUST 1998, VOL. 14 1998 © The Japan Society for Analytical Chemistry The preparation of atrazine-receptor polymers by molecular imprinting was explored, focusing upon the role of functional monomer and solvent used for the preparation....

show abstract

Section: Solvents Used For Polymer Preparationmentioning

confidence: 51%

Design and Preparation of Molecularly Imprinted Atrazine-Receptor Polymers: Investigation of Functional Monomers and Solvents

1998

View full text Add to dashboard Cite

show abstract

“…This phenomenon also can be seen from a former paper about atrazine MIPs [16]. This may be attributed to the solvent used in the preparation process [24]: solvents also engaged as templates during the imprinting process and affected the binding ability of resultant polymers, and solvent effects on the resultant selectivity have been reported by Hosoya [32]. However the mechanism was unknown now.…”

Section: Molecular Selectivity Of Mipsmentioning

confidence: 54%

Molecularly imprinted polymers by reversible addition–fragmentation chain transfer precipitation polymerization for preconcentration of atrazine in food matrices

Chen

2011

Talanta

111

View full text Add to dashboard Cite

“…There are several factors that influence the polymerisation, and hence the subsequent performance of the IIPs. These factors include the nature and masses of monomers Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999), crosslinkers (Wulff and Sarchan, 1972;Yan and Ramström, 2005;Zhu et al, 2007;Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999;Holland et al, 2010;Mijangos et al, 2006), porogen (Arshady andMosbach, 1981 andWulff andSarchan, 1972;Yan and Ramström, 2005;Zhu et al, 2007;Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Holland et al, 2010;Mijangos et al, 2006;Yoshizako et al, 1998), template (Yilmaz et al, 1999;Zhang and Li, 2006;He et al, 2007;…”

Section: Introductionmentioning

confidence: 99%

“…There are several approaches that can be used to optimise these parameters (Yu and Mosbach, 2000;Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999;Holland et al, 2010;Mijangos et al, 2006;Yoshizako et al, 1998;Chu and Lin, 2003). Most have reported an approach where a single parameter was varied with others kept constant Zhang et al, 2005;Zhang and Li, 2006;Song et al, 2009;Kim and Spivak, 2003;Holland et al, 2010 Yoshizako et al, 1998;Chu and Lin, 2003). However, other groups varied more than one parameter at a time Okutucu and Telefoncu, 2008;Piletska et al, 2009;Yilmaz et al, 1999;Andersson et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…The most important parameters that determine the performance of IIPs are the molar ratios of crosslinkers to monomers (Yan and Ramström, 2005;Zhu et al, 2007;Yu and Mosbach, 2000;He et al, 2007;Spivak, 2005), monomers to template (Yan and Ramström, 2005;Yu and Mosbach, 2000;Yilmaz et al, 1999;Zhang and Li, 2006;He et al, 2007;Kim and Spivak, 2003;Andersson et al, 1999;Spivak, 2005), the volume and type of porogen (Yan and Ramström, 2005;Yu and Mosbach, 2000;Song et al, 2009;He et al, 2007;Yoshizako et al, 1998;Spivak, 2003) and the initiator used (Piletska et al, 2009;Mijangos et al, 2006;Yanagihara et al, 1999). The volume/mass of template used ought to be optimised, because increasing the concentration of the components in the polymerisation mixture will favour an increase in the pre-polymer complex, according to Le Chatelier's principle.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Optimal synthesis of a Ni(II)-dimethylglyoxime ion-imprinted polymer for the enrichment of Ni(II) ions in water, soil and mine tailing samples

Rammika¹,

Darko²,

Torto³

2012

WSA

View full text Add to dashboard Cite

A Ni(II)-dimethylglyoxime ion-imprinted polymer {Ni(II)-DMG IIP} was optimised by the uniform design experimental method and used to adsorb Ni(II) ions from water, soil and mine tailing samples. This aimed to improve the performance of this ion-imprinted polymer in trapping Ni(II) ions from soil and mine tailing samples which are characterised by complex matrices. The optimisation was carried out by varying the molar ratios of monomer to crosslinker to porogen and template to ligands, as well as by keeping these parameters constant and varying the concentrations of initiator, 2,2'-azobisisobutyronitrile (AIBN). The optimal molar ratios of crosslinker to monomer, monomer to template and nickel(II) sulphate hexahydrate (NiSO 4 .6H 2 O) to 4-vinylpyridine to dimethylglyoxime were found to be 3.3:1.0, 0.6:1.0 and 1.0:0.6:3.6, respectively, with 30 mg and 8 mℓ as the optimum amounts of initiator and porogen, respectively. Through this optimisation, extraction efficiency for Ni(II) increased from 98 to 100% in aqueous samples. The extraction efficiencies for the soil and mine tailing samples were 98-99% and 99%, respectively, with an enrichment factor of 2 in mine tailing samples and ranging from 27 to 40 in soil samples. The method displayed good accuracy, as it was validated with certified reference materials (SEP-3 and BCR-142R) and the values obtained were close to the certified ones. The improved quality of results obtained from water, soil and mine tailing samples showed that the uniform design experimental method is effective and efficient for optimising imprinted polymers using a lower number of experiments performed.

show abstract

Porogen Imprinting Effects

Cited by 88 publications

References 10 publications

Design and Preparation of Molecularly Imprinted Atrazine-Receptor Polymers: Investigation of Functional Monomers and Solvents

Design and Preparation of Molecularly Imprinted Atrazine-Receptor Polymers: Investigation of Functional Monomers and Solvents

Molecularly imprinted polymers by reversible addition–fragmentation chain transfer precipitation polymerization for preconcentration of atrazine in food matrices

Optimal synthesis of a Ni(II)-dimethylglyoxime ion-imprinted polymer for the enrichment of Ni(II) ions in water, soil and mine tailing samples

Contact Info

Product

Resources

About