Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis

Ye, Haixin; Ma, Shuoyi; Qiu, Zhantu; Huang, Sha; Deng, Guanghui; Li, Yunjia; Xu, Shu; Yang, Menghan; Sheng, Hao; Wu, Chaofeng; Li, Min; Zhang, Jia; Zhang, Fengxian; Qin, Mengchen; Huang, Huacong; Zeng, Zhiyun; Wang, Ming; Chen, Yuyao; Lin, Haiyan; Gao, Zhuowei; Cai, Min; Song, Yu; Gong, Shenhai; Gao, Lei

doi:10.1016/j.jep.2022.115457

Cited by 37 publications

(16 citation statements)

References 35 publications

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“…In recent years, researchers aiming to elucidate the pharmacodynamic mechanism of Poria cocos turned their attention to the PCPs which account for 70-90% of its total weight and are its most important bioactive substance [20]. PCPs exhibit beneficial lipid regulation, anti-inflammatory, antioxidant, and immunomodulatory effects [21,22]. Several recent studies have shown that PCPs can alter the gut microbiome to improve normal intestinal physiological function; however, how the altered gut microbiome is involved in improving intestinal physiological function deserves more in-depth study [23,24].…”

Section: Discussionmentioning

confidence: 99%

Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles

Feng,

Liu,

et al. 2023

Nutrients

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Previous studies found that Poria cocos polysaccharides (PCPs) significantly enhanced the antioxidant activity in piglet intestines while increasing the abundance of Lactobacillus. However, the relationship between Lactobacillus and antioxidant activity has yet to be verified, and the mode of action needs further investigation. Six Lactobacillus strains isolated from the intestines of neonatal piglets fed with PCPs were studied to investigate the relationship between Lactobacillus and intestinal oxidative stress. The results showed that three of them alleviated intestinal oxidative stress and protected the intestinal barrier. Subsequently, we extracted the extracellular vesicles (EVs) of these three Lactobacillus strains to verify their intestinal protection mode of action. We found that these EVs exerted an excellent antioxidant effect and intestinal barrier protection and could directly improve intestinal microbial composition. Our findings suggested that the EVs of the three Lactobacillus strains could enhance antioxidant activity by improving the physical intestinal barrier and remodeling gut microbiota. Unlike probiotics, which should be pre-colonized, EVs can act directly on the intestines. This study provides new ideas for the subsequent development of products to protect intestinal health.

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Section: Discussionmentioning

confidence: 99%

Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles

Feng,

Liu,

et al. 2023

Nutrients

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“…Polysaccharides could improve NAFLD through protecting the intestinal barrier. Ye et al (49) evaluated the therapeutic effect of Poria cocos polysaccharides (PCP) on HFD-induced NASH mice. It was found that PCP reduced pyroptosis-driven gut vascular barrier disruption and entry of endotoxin into the circulation caused by a high-fat diet, thereby ameliorating the inflammation.…”

Section: Targeting Gut-liver Axismentioning

confidence: 99%

Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases

Ma²,

Dong³

et al. 2023

Front. Nutr.

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Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease and is a leading cause of cirrhosis and hepatocellular carcinoma. Due to its complex pathophysiology, there is currently no approved therapy. Polysaccharide, a kind of natural product, possesses a wide range of pharmacological activities. Numerous preclinical studies have confirmed that polysaccharides could interfere with the occurrence and development of NAFLD at multiple interrelated levels, such as improvement of glucose and lipid metabolism, antioxidation, anti-inflammation, and regulation of gut-liver axis, thus showing great potential as novel anti-NAFLD drugs. In this paper, we reviewed the polysaccharides with anti-NAFLD effect in recent years, and also systematically analyzed their possible pharmacological mechanisms.

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“…These effects improved systemic inflammation in the ileum and liver, reduced the damage and penetration of LPS to the intestinal mucosa, and alleviated the NAFLD process under the co-regulation of other pathways (e.g., the SCFA pathway). Ye et al [ 116 ] studied the ameliorating effect of Poria cocos polysaccharide (PCP) on NAFLD and explored its underlying mechanism. The results showed that PCP could effectively improve the liver injury of NAFLD.…”

Section: Ameliorative Effects Of Polysaccharides On Nafld Via the Gut...mentioning

confidence: 99%

Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis

Chen

Liu

Tang

et al. 2022

IJMS

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease affecting global public health at present, which can induce cirrhosis and liver cancer in serious cases. However, NAFLD is a multifactorial disease, and there is still a lack of research on its mechanism and therapeutic strategy. With the development of the gut–liver axis theory, the association between the gut–liver axis and the pathogenesis of NAFLD has been gradually disclosed. Polysaccharides, as a kind of natural product, have the advantages of low toxicity, multi-target and multi-pathway action. It has been reported that polysaccharides can affect the gut–liver axis at multiple interrelated levels, such as maintaining the ecological balance of gut microbiota (GM), regulating the metabolites of GM and improving the intestinal barrier function, which thereby plays a protective role in NAFLD. These studies have great scientific significance in understanding NAFLD based on the gut–liver axis and developing safe and effective medical treatments. Herein, we reviewed the recent progress of polysaccharides in improving nonalcoholic fatty liver disease (NAFLD) through the gut–liver axis.

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Poria cocos polysaccharides rescue pyroptosis-driven gut vascular barrier disruption in order to alleviates non-alcoholic steatohepatitis

Cited by 37 publications

References 35 publications

Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles

Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles

Research progress on the therapeutic effects of polysaccharides on non-alcoholic fatty liver diseases

Research Progress on the Therapeutic Effect of Polysaccharides on Non-Alcoholic Fatty Liver Disease through the Regulation of the Gut–Liver Axis

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