Poria acid alleviates oxidative damage in mice with dry age-related macular degeneration by activating the Nrf2/HO-1 signaling pathway
Chengyao Qin,
Xi Chen,
Tianming Hu
et al.
Abstract:Background
Poria acid (PA) extracted from the traditional Chinese medicinal herb Poria cocos (P cocos) is reported to protect organs such as the liver and lungs from damage. However, its effect on dry age-related macular degeneration (AMD) has not been reported. This research is to investigate the influence of PA on oxidative stress of the retina in vivo and in vitro.
Methods
In vitro, the viability of ARPE-19 cells was measured by the MTT. The apoptosis of the cells was detected by Flow cytometry and the ex… Show more
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