Pore formation in complex biological membranes: torn between evolutionary needs
Leonhard J. Starke,
Christoph Allolio,
Jochen S. Hub
Abstract:The primary function of biological membranes is to enable compartmentalization among cells and organelles. Loss of integrity by the formation of membrane pores would trigger uncontrolled depolarization or influx of toxic compounds, posing a fatal thread to living cells. How the lipid complexity of biological membranes enables mechanical stability against pore formation while simultaneously allowing ongoing membrane remodeling is largely enigmatic. We performed molecular dynamics simulations of eight complex li… Show more
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