Pore formation by pore forming membrane proteins towards infections

IgG Fc-binding protein positively regulates the assembly of pore-forming protein complex βγ-CAT evolved to drive cell vesicular delivery and transport

“…Pore-forming proteins (PFPs) in various families with structural folds are widely distributed in all kingdoms of life ( 5 , 6 , 7 , 8 , 9 ). PFPs have long been recognized as either pore-forming toxin for microbial infection ( 6 , 10 , 11 ) or host immune executors ( 12 , 13 , 14 , 15 ). In particular, aerolysin is a bacterial β-barrel pore-forming toxin ( 16 , 17 ).…”