Pore characterization of PM Mg–0.6Ca alloy and its degradation behavior under physiological conditions

Nidadavolu, Eshwara Phani Shubhakar; Krüger, Diana; Zeller‐Plumhoff, Berit; Tolnai, D.; Wiese, Björn; Feyerabend, Frank; Ebel, Thomas; Willumeit‐Römer, Regine

doi:10.1016/j.jma.2020.05.006

Cited by 15 publications

(9 citation statements)

References 60 publications

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“…24 Additionally, the high pore interconnectivity is a dominant factor controlling degradation. 25 Figure 1b,e shows that EIS plots of both alloys were composed of one high−mediumfrequency capacitance loop. They existed at all of the curves, suggesting the generation of pitting corrosion in the whole corrosion process, which is similar to ref 26.…”

Section: In Vitro Degradation Adaptability Evaluationmentioning

confidence: 95%

Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications

Luo,

Li,

Cai

et al. 2023

ACS Appl. Bio Mater.

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Section: In Vitro Degradation Adaptability Evaluationmentioning

confidence: 95%

Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications

Luo,

Li,

Cai

et al. 2023

ACS Appl. Bio Mater.

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“…[76] The sintering process generally results in a nearly dense microstructure, providing some residual porosity depending on the alloying system, sintering temperature and time, and applied pressure. [76,77] As the porosity determines the mechanical and degradation properties of the material, it is of particular interest. Depending on the pore size, SRμCT can be used to determine the porosity, [78] as well as indirect techniques such as SAXS.…”

Section: Powder Metallurgymentioning

confidence: 99%

Section: Alloy Developmentmentioning

confidence: 99%

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Utilizing Synchrotron Radiation for the Characterization of Biodegradable Magnesium Alloys—From Alloy Development to the Application as Implant Material

et al. 2021

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Magnesium (Mg)-based alloys are investigated for the use as lightweight structural metals, e.g., in the automotive industry, [1] as biodegradable implant materials [2] and for hydrogen storage. [3] The choice of alloying system and subsequent processing of the material is a crucial factor for the degradation profile of the alloy and its mechanical properties. [4][5][6][7] This review focuses on use of Mg alloys as implant material, with some references to its application as a structural metal.The degradation profile of Mg alloys is of particular importance for their application as implant materials, as a controlled degradation is required to ensure cell viability and implant stability in vivo. [8,9] During the development of Mg alloys for the application as a biodegradable implant, alloying systems are carefully selected and manufactured, with their microstructure being tailored according to specifications by selecting the appropriate processing route. The microstructure and the mechanical properties of the alloy will be evaluated and the alloy is then tested for in vitro degradation in an aqueous environment under physiological conditions (pH %7.4, 37 C, 5% CO 2 , 21% O 2 , 95% rel. humidity) with and without cells to assess its general degradation properties and cell viability. [10] The mechanical properties and degradation profile need to be tailored depending on the application of the implant. Mg alloys for bone support, for example, require mechanical properties close to that of bone. For bone, the average Young's modulus is between 7 and 31 GPa, depending on the type of bone and its hydration state. [11,12] In longitudinal direction, the bone's tensile and compressive ultimate strength have been reported to be between 93 and 135 MPa, and 154 and 205 MPa, respectively. [13,14] Finally, the elongation to failure of the clinically approved MAGNEZIX screw by Syntellix AG (Hanover, Germany) was determined to be 8%. [15] By contrast, Mg alloys designed for the use as stents must possess a minimum ultimate tensile strength of 300 MPa, low yield strength of 200-300 MPa, and higher ductility (min. 15%-18% elongation to failure, preferably 30%) for their successful deployment. [16,17] Finally, in vivo animal experiments are conducted to evaluate the alloy suitability for the translation into the clinic.

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“…One approach for a significant decrease of the corrosion degradation rate has been the modification of the Mg-Ca0.8 surface by wollastonite (CaSiO 3 ) and β-tricalcium phosphate [Ca 3 (PO 4 ) 2 ] micro-arc coatings [72,73]. Reported studies compare the degradation behavior of Mg-Ca alloys (0.3, 0.6, and 0.9 %Ca) under physiological conditions, such as the culture medium DMEM glutamax + 10% FBS-Fetal serum bovine + 1% penicillin streptomycin) [74][75][76]. The average grain size has been determined by optical microcopy and reported as: 18.6 ± 1.2 µm (Mg-Ca0.3), 17.6 ± 1.9 µm (Mg-Ca0.6), and 20.5 ± 1.2 µm (Mg-Ca0.9).…”

Section: Introductionmentioning

confidence: 99%

Mg-Ca0.3 Electrochemical Activity Exposed to Hank’s Physiological Solution and Properties of Ag-Nano-Particles Deposits

González-Murguía

Véleva

Rodríguez‐Gattorno

et al. 2021

Metals

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This work compares the degradation of Mg and Mg-Ca0.3 alloy when they are exposed for 14 days to Hank’s solution at 37 °C. A combination of immersion test, electrochemical techniques (PDP, EIS, EN), and surface characterization methods (SEM-EDS, XRD, and XPS) were carried out. The pH change over time, the lower mass loss (≈20%), and the lower concentration of the released Mg2+ ions (≈3.6 times), as well as the lower level of the surface degradation, allowed to consider the positive effect of Ca, presenting Mg-Ca0.3 alloy with lower electrochemical activity than that of Mg. The positive effect of Ca may be due to the formed layer characteristics on the alloy surface, which impedes the cathodic hydrogen evolution and Mg-ions release. The electroless deposited Ag-nano-particles (Ag-NPs) on Mg-Ca0.3 surface were characterized by SEM-EDS, XRD, UV-Vis, and contact angle. The agar-diffusion test was used to compare the growth of Staphylococcus aureus and Escherichia coli bacteria on Mg-Ca0.3 in the presence of Ag-NPs deposits in different size. Zeta-potential of the bacteria was negative, with respect to pH of the Mueller-Hinton culture broth. The greater antibacterial effect of S. aureus was attributed to its more negative zeta-potential, attracting more released Ag+ ions.

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Pore characterization of PM Mg–0.6Ca alloy and its degradation behavior under physiological conditions

Cited by 15 publications

References 60 publications

Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications

Degradation Adaptability Assessment of Semisolid Powder Molded Mg–Zn–Mn Alloys for Orthopedic Applications

Utilizing Synchrotron Radiation for the Characterization of Biodegradable Magnesium Alloys—From Alloy Development to the Application as Implant Material

Mg-Ca0.3 Electrochemical Activity Exposed to Hank’s Physiological Solution and Properties of Ag-Nano-Particles Deposits

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