Porcine urinary bladder extracellular matrix grafts (ACell Vet^®Corneal Discs) for keratomalacia in 17 equids (2012–2013)

Abstract

Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.

Modified penetrating keratoplasty with Acell® bioscaffold implant in seven horses with deep full‐thickness corneal stromal abscess

“…This would support observations in Mancuso, et al 33 Although considered a relatively inert material, a rejection response has been documented in both small and large animals. In patient 6, adjustment of the topical NSAID was adequate to resolve the inflammation while the uveitis was completely unresponsive in the other.…”

“…There have been limited reports using porcine intestinal submucosa implantation in equine corneal surgery. 2,28,29,33 In one report, three patients were treated for DSA with a penetrating keratoplasty, SIS implant, and conjunctival graft. All three patients retained functional vision, with anterior synechiae, posterior synechiae, and subcapsular cataract formation.…”

The use of porcine urinary bladder matrix (UBM) to repair a perforated corneal ulcer with iris prolapse in a horse

“…However, conjunctival tissue remains at the site of graft, resulting in a permanent corneal opacity (Mancuso et al . ). While this may be tolerable in small lesions it can significantly impair vision when large grafts are required.…”

“…Clinical reports have demonstrated its benefits for corneal repair, which are similar to those achieved with conjunctival autografts, but with less post‐operative complications (Mancuso et al . ).…”

Ulcerative keratitis and keratomalacia in horses: Medical management and surgical considerations

“…; Chow and Westermeyer ) and in horses with partial thickness ulcerative keratitis (Mancuso et al . ). It is eventually degraded and replaced with host tissue; when used as a sole therapy this may be associated with less post‐operative discomfort and corneal scarring, although further studies are necessary to support these claims.…”