Porcine small intestine submucosal graft for endoscopic skull base reconstruction

Abstract

Use of porcine SIS dural graft was associated with excellent outcomes in this study and evidence presented here supports its routine use in the endoscopic closure of skull base defects.

Management of cerebrospinal fluid rhinorrhea: an evidence‐based review with recommendations

“…used a nasoseptal flap as a final layer. Similarly, Illing et al . used porcine small intestine submucosal grafts in 155 patients, often along with a nasoseptal flap.…”

Changing the surgical dogma in frontal sinus trauma: transnasal endoscopic repair

“…Overlay grafts or nasoseptal flaps (NSF) were used without underlay repairs for simple cracks or when an isolated telescoped segment of posterior table had been manually reduced. If fragments were removed and defects were larger than approximately 5 mm, an underlay epidural repair with porcine small intestine submucosal (SIS) graft (Biodesign®, Cook Medical, Bloomington, IN) was included prior to overlay graft or flap placement . Nasoseptal flaps were harvested as previously described and can cover up to 3 cm of ipsilateral posterior table defects …”

Draf III mucosal graft technique: long‐term results

“…If a portion of the posterior table of the frontal sinus was resected or a cerebrospinal fluid (CSF) leak was present, the nasoseptal flap or free grafts were used for coverage during skull-base repair. [8][9][10][11] The perichondrial/periosteal side of the septal or turbinate mucosal grafts were thinned if necessary to 1 to 2 mm thickness and placed over exposed bone of the nasofrontal beak. Silastic frontal sinus stents, 0.5 mm thickness, were then inserted to support the mucosal grafts.…”