Porcine Skin Collagen Implants to Prevent Anterior Vaginal Wall Prolapse Recurrence: A Multicenter, Randomized Study

Meschìa, Michele; Pifarotti, P.; Bernasconi, F.; Magatti, F.; Riva, Diego Della; Kocjancic, E.

doi:10.1016/j.juro.2006.08.100

Cited by 114 publications

(78 citation statements)

References 16 publications

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“…18 Multiple studies have not demonstrated any difference in surgery with or without meshes. 7,23,24 An advantage, however, was shown in surgery with prosthesis. 25 We used a non-validated questionnaire, but a set of short questions including simple clinical data, limiting the extrapolation of our own results.…”

Section: Discussionmentioning

confidence: 99%

Morbidity and functional mid-term outcomes using the Prolift pelvic floor repair systems

Kozal

Ripert²,

Bayoud

et al. 2014

CUAJ

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Introduction: We assess midterm morbidity and functional outcomes using the Prolift (Gynecare/Ethicon, Somerville, NJ) system and identify potential related risk factors. The Prolift mesh system to treat genital prolapse was introduced in 2005. It was withdrawn from the market in early 2013 after rising doubts about safety. Methods: Over a 7-year period, we retrospectively analyzed a cohort of 112 consecutive patients who underwent the Prolift procedure since 2006. Intraoperative and postoperative complications, anatomical and functional outcomes were recorded. Results: The median follow-up was 49.5 months (range: 16-85). The mean age was 64.7 ± 10.9 years (range: 40-86). Of the 112 patients, 74 patients had stage 3 (66.1%) and 8 patients had stage 4 (7.14%) vaginal prolapse. Prolift surgery was performed for prolapse recurrence for 26 patients (23.2%). Total mesh was used in 32 patients (29%), an isolated anterior mesh in 57 patients (51%) and an isolated posterior mesh in 23 patients (21%). Concomitant surgical procedures were performed for 44 patients (39.3%). Overall, 72% (18/25) of the complications were managed medically. We reported a failure rate of 8% (n = 9) occurring after a median followup of 9.5 months (range: 1-45). Among the 64 patients who had preoperative sexual activity (57.1%), de novo dyspareunia occurred in 9 patients (16.07%). We extracted predictive factors concerning failure, complications and sexuality. Conclusion: Despite its market withdrawal, the Prolift system was associated with good midterm anatomic outcomes and few severe complications. Long-term follow-up data are still lacking, but surgeons and patients may be reassured.

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Section: Discussionmentioning

confidence: 99%

Morbidity and functional mid-term outcomes using the Prolift pelvic floor repair systems

Kozal

Ripert²,

Bayoud

et al. 2014

CUAJ

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“…Sixteen randomized trials matching our inclusion criteria were published: one in 2006 [5], two in 2007 [6,7], four in 2008 [8][9][10][11], four in 2009 [12][13][14][15] and five in 2010 [16][17][18][19][20]. We added two publications of Nieminen, reporting long-term results of the randomized trial initially written by Hiltunen in 2007 [6,21,22].…”

Section: Resultsmentioning

confidence: 99%

“…Twelve studied non-absorbable synthetic (NAS) polypropylene implants [6, 8-12, 14, 16, 19-22] and six absorbable biomesh (AB) [5,7,13,15,17,18]. Anatomic results are summed up in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…In randomized studies, there was no significant difference between the two techniques (traditional surgery or using graft) when comparing "average blood loss" (596 patients in seven studies) [5,7,13,14,[18][19][20] or "important blood loss" (446 patients in four studies) [6,9,12,17]. A superior blood loss in the group with prosthetic reinforcement was found by Hiltunen and Altman [6,23].…”

Section: Bleedingmentioning

confidence: 92%

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Use of vaginal mesh for pelvic organ prolapse repair: a literature review

et al. 2011

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The use of mesh for pelvic organ prolapse repair through the vaginal route has increased during this last decade. The objective is to improve anatomical results (sacropexy with mesh seeming better than traditional surgery) and keep still the advantage of vaginal route. Numbers of cohort series and randomized control trials have been recently published. These works increase our knowledge of advantages and risks of mesh. It has been shown that the use of mesh to treat cystocoele through vaginal route improves anatomical results when compared to traditional surgery. The rate of complications, especially de novo dyspareunia, remains equivalent between the two techniques.

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“…Meta-analysis of randomized studies showed that Pelvicol ® augmentation did not offer better results than anterior repair (RR: 1.3; 95% CI: 0.8-2.2). Only one RCT [91] reported superior results following Pelvicol ® augmentation. This did not change, even when the results of all studies which used any type of biological implant were combined; the use of biological graft material did not appear to improve success rates (RR: 1.34; 95 % CI: 0.97-1.86).…”

Section: Level Of Evidence 3 Grade Of Recommendation Bmentioning

confidence: 99%

Diagnosis and Therapy of Female Pelvic Organ Prolapse. Guideline of the DGGG, SGGG and OEGGG (S2e-Level, AWMF Registry Number 015/006, April 2016)

Baeßler

Aigmüller

Albrich

et al. 2016

Geburtshilfe Frauenheilkd

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Ziel: Erstellung einer offiziellen, internationalen, interdisziplinären Leitlinie, publiziert und koordiniert von der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Die Leitlinie wurde für den deutschsprachigen Raum entwickelt und wird neben der DGGG auch von der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe (SGGG) und der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) mitgetragen. Das Ziel dieser Leitlinie, die von der DGGG publiziert und koordiniert wurde, ist es, durch die Evaluation der relevanten Literatur einen evidenzbasierten Überblick über die Diagnostik sowie konservative und operative Therapie des Descensus genitalis der Frau mit oder ohne Belastungsinkontinenz zu geben. Methoden: Es erfolgte ein systematischer Review sowie Synthese von Daten, anteilig mit Metaanalyse (S2e). Es wurde eine umfassende Literatursuche in MEDLINE, Embase, Cinahl, Pedro und im Cochrane-Register, in Referenzlisten und in den Abstracts der Annual Meetings der International Continence Society und der International Urogynecological Association durchgeführt. Abstracts wurden eingeschlossen, wenn es sich um randomisierte Studien handelte, die als Podiumpräsentation vorgestellt und diskutiert wurden. Es wurden Originalarbeiten seit 2008 eingeschlossen, deren Nachkontrollzeitraum bei mindestens 12 Monaten lag. Für die Beschreibung von perioperativen Komplikationen wurden jegliche Daten herangezogen. Empfehlungen: Es werden Empfehlungen zur Diagnostik, konservativen und operativen Therapie des Genitaldeszensus gegeben, wobei die 3 urogynäkologischen Kompartimente, Prävention oder Behandlung von Belastungsinkontinenz, Vor-und Nachteile von Netzaugmentationen sowie uteruserhaltende Optionen, berücksichtigt

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Porcine Skin Collagen Implants to Prevent Anterior Vaginal Wall Prolapse Recurrence: A Multicenter, Randomized Study

Abstract: Our data show that the Pelvicol implant can be easily and readily used to augment and reinforce anterior colporrhaphy. The prolapse recurrence rate was considerably lower in the implant group compared with outcomes in patients treated with simple anterior repair.

Cited by 114 publications

References 16 publications

Morbidity and functional mid-term outcomes using the Prolift pelvic floor repair systems

Morbidity and functional mid-term outcomes using the Prolift pelvic floor repair systems

Use of vaginal mesh for pelvic organ prolapse repair: a literature review

Diagnosis and Therapy of Female Pelvic Organ Prolapse. Guideline of the DGGG, SGGG and OEGGG (S2e-Level, AWMF Registry Number 015/006, April 2016)

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