Porcine pancreas lipase as a green catalyst for synthesis of bis-4-hydroxy coumarins

Biocatalytic decarboxylative Michael addition for synthesis of 1,4-benzoxazinone derivatives

“…The concept of green chemistry is intrinsically linked to enzymatic catalysis, as enzymes can be obtained from renewable sources, and are capable of catalyzing various chemical reactions, being an alternative to the classical chemical catalysis 17 – 21 . The ability of enzymes to catalyze multiple distinctly different reactions is referred to as enzyme promiscuity 22 – 24 , Lipases (EC 3.1.1.3, carboxylesterase enzyme) 25 , 26 have previously shown unexpected activities and have been used in organic reactions such as Aldol condensation 27 , Hantzsch reaction 28 , Cannizzaro reaction 29 , Mannich reaction 30 , Baylis–Hillman reaction 31 , Knoevenagel condensation 32 , Michael addition 33 and Ugi reaction 34 .…”

Lipases: Sources of Acquisition, Ways of Production, and Recent Applications

“…Reference Sus scrofa domesticus [25,27,28,51] Hexaplex trunculus [52] Gryllus bimaculatus [53] Thunnus orientalis, Totoaba macdonaldi, Morone saxatilis [54] Table 3 Microbial sources for lipase production.…”

Biocatalytic synthesis of oxadiazole thioethers and evaluation of their antitumor activity

“…[19][20][21][22][23][24] Hence, lipases are not only used for catalyzing conventional reactions, such as hydrolysis, transesterification, esterification, [25][26][27] and kinetic resolutions, [28][29][30] but also unconventional reactions. 31,32 Indeed, different chemical transformations catalyzed by lipases to form C-C, C-N, and C-S bonds through promiscuous mechanisms have been reported, 31 some of which are the Knoevenagel condensation, 33 Michael addition, 34,35 aldol, 20 Hantzsch, 21 Mannich 22 and Cannizzaro reactions. 23 Knoevenagel condensations, as a variant of aldol condensations, are one of the fundamental reactions in organic synthesis to form carbon-carbon double bonds.…”