Porcine Monocyte DNA Traps Formed during Infection with Pathogenic Clostridioides difficile Strains
Jade Lawrence,
Paul Barrow,
Neil Foster
Abstract:Clostridioides (Clostridium) difficile is an enteric pathogen of several mammalian species including man, frequently involving nosocomial resurgence, following oral administration of broad-spectrum antibiotics, but also with human-to-human infection occurring, and neonatal pigs with zoonotic transmission. To date, the immune response to C. difficile has mostly focused on neutrophils and cytokine/chemokines, particularly in human infection. The neonatal pig is now recognized as a valuable model for human infect… Show more
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