Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis

Lillie, Brandon N.; Hammermueller, Jutta; MacInnes, Janet I.; Jacques, Mario; Hayes, Michael

doi:10.1016/j.dci.2005.12.008

Cited by 30 publications

(28 citation statements)

References 53 publications

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“…MBL1 gene was proposed as an indirect marker to improve dairy mastitis resistance traits in cattle [24]. SNPs of MBL1 gene in various breeds of pigs were found to be associated with impaired disease resistance [25]. Both MBL1and MBL2 gene mutations were found to be having impact on susceptibility to different infections [26].…”

Section: Discussionmentioning

confidence: 99%

Association study of genetic variants at single nucleotide polymorphism rs109231409 of mannose-binding lectins 1 gene with mastitis susceptibility in Vrindavani crossbred cattle

Asaf¹,

Bhushan²,

Panigrahi³

et al. 2014

Vet World

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Aim: The present study was undertaken to identify whether single nucleotide polymorphism (SNP) rs109231409 located on mannose-binding lectins 1 (MBL1) gene was associated with mastitis tolerance/susceptibility. Materials and Methods:After grouping 100 Vrindavani crossbred cattle as mastitis positive and negative animals, they were genotyped using polymerase chain reaction (PCR)-restriction fragment length polymorphisms method. Gene and genotype frequencies of different patterns were estimated by standard procedure (POPGENE version 1.32, (University of Alberta, Canada) and statistical analysis was carried out by logistic regression methods using STATA 12 software (StataCorp LP, USA). Results:The 588 bp fragment of MBL1 gene was amplified using PCR. PCR product was digested with ApaI restriction enzyme showed two distinct genotypes viz., GG (311 bp and 272 bp fragments) and GA (588 bp, 311 bp and 277 bp fragments). The gene, genotype frequencies, average heterozygosity, polymorphic information content and χ 2 values for the locus rs109231409 was ascertained. Conclusions:No significant association between SNP "rs109231409" with mastitis tolerance was found. Although there is a lack of association, further studies have to be undertaken in a large population in order to validate the impact of rs109231409 (g.855G >A) on mastitis tolerance.

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Section: Discussionmentioning

confidence: 99%

Association study of genetic variants at single nucleotide polymorphism rs109231409 of mannose-binding lectins 1 gene with mastitis susceptibility in Vrindavani crossbred cattle

Asaf¹,

Bhushan²,

Panigrahi³

et al. 2014

Vet World

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“…Functional MBL is a multimeric protein of up to six 96 kDa subunits, which consisted of 3 identical polypeptide chains pro-duced by the liver. There are two pathways by which MBL can participate in a host defense response: 1) MBL activates the lectin complement pathway via MBL associated serine proteases (MASPs), that con-verges with the classical complement pathway, at the level of complement C4, and 2) MBL may also act directly as an opsonin, enhancing phagocytosis by binding to cell-surface receptors present on phagocytic cells [5,6] . Several reports suggest that MBL deficiency also predisposes to autoimmune disease, such as systemic lupus erythematosus [10,11] , and rheumatoid arthritis [12] .…”

Section: Discussionmentioning

confidence: 99%

“…The MBL -defect could result in many kinds of acute or chronic pathogen infections. Abnormal serum MBL levels might also cause certain autoimmune diseases, the mutations in exon-1 of the human MBL gene can interfere the formation of a stable MBL functional polymer which decreased serum MBL levels and lowered the body's physiological function significantly, such as Systemic lupus erythematosus, Clinical repeated infections, Hepatitis B virus, and other viral infections in humans [2][3][4][5] ; Similarly, some other studies also reported that A-type MBL can has antibacterial function against Porcine Actinobacillus, Actinobacillus pleuropneumoniae, Haemophilus parasuis [6,7] . It showed that MBL plays a vital role in the activation of the complement pathway as antiinfective molecules.…”

Section: Study Of Mbl In Sheepmentioning

confidence: 99%

Koyunlarda Mannoz Bağlayan Lektin (MBL) Polimorfizmi ve Mycoplasma ovipneumoniae Enfeksiyonu Sonrasında Serum MBL Protein Seviyeleri İle İlişkisi

Heng¹,

Yang²,

Liang³

et al. 2017

Kafkas Univ Vet Fak Derg

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Mannose Binding Lectin (MBL) is a liver-derived, circulating plasma protein that plays a pivotal role in innate immunity, however, MBL polymorphisms in sheep were associated with the incidence of MO infection. The objective of this study was to determine the relationships between the different genotypes of MBL and the resistance against MO infection disease, including three hundred and thirty-six individuals of the China Merino sheep. Single-Strand Conformation Polymorphism (SSCP) analyses of PCR amplicons of the exon-1 region of the MBL gene revealed four patterns: BB, BC, CC and DD. However, BB, BC and DD genotype have 3 SNPs, 2 SNPs, and 4 SNPs respectively, and CC genotype has only an identical sequence to the reference, among which there are 3 synonymous SNPs and 6 non-synonymous SNPs. Our statistic analysis showed that the DD genotype MBLs in China Merino sheep were associated with the decrease of MBL protein level in serum. The sheep carrying this kind of genotype were more susceptible to MO infection, however, an opposite result was found in sheep having CC genotype, which will provide a reference for molecular breeding of sheep breeds resistant to MO infection. Keywords: Polymorphisms, China Merino sheep, Mannose-binding lectin, PCR-SSCP, Mycoplasma ovipneumoniae infection Koyunlarda Mannoz Bağlayan Lektin (MBL) Polimorfizmi ve

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“…Some commercial A. pleuropneumoniae vaccines, containing Apx toxoids, might provide some cross protection. Furthermore, Lillie et al (2006) characterized porcine plasma lectins with bacteria-binding functions against A. suis and Haemophilus parasuis which may play a role on innate resistance to bacterial pathogens in pigs.…”

Section: Characteristics Of Actinobacillus Suis and Actinobacillus Eqmentioning

confidence: 99%

Actinobacillus suis and Actinobacillus equuli, emergent pathogens of septic embolic nephritis, a new challenge for the swine industry

Benavente

Fuentealba

2012

Arch. med. vet.

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Actinobacillus suis and Actinobacillus equuli, emergent pathogens of septic embolic nephritis, a new challenge for the swine industryActinobacillus suis y Actinobacillus equuli, patógenos emergentes de nefritis embólica séptica, un nuevo desafío para la industria porcina RESUMENLas lesiones renales son una causa importante de decomiso en los mataderos. Además de las posibles consecuencias en salud pública, el decomiso de órganos tiene un gran impacto económico en la industria de alimento animal. Recientemente, nefritis embólica séptica con lesiones semejantes a infecciones con Actinobacillus equuli en potrillos ha sido detectada en reproductoras y cerdos con peso de mercado. Actinobacillus equuli es fenotípica y genéticamente similar a Actinobacillus suis. Ambas son bacterias Gram-negativas difíciles de diagnosticar en exámenes de rutina. A. suis es un patógeno oportunista capaz de producir septicemia en cerdos, neumonía, poliartritis, nefritis embólica séptica, aborto y fetos momificados. Brotes de la enfermedad clínica parecieran ocurrir con más frecuencia en planteles de cerdos con estrictas medidas de bioseguridad. En cerdos adultos, las lesiones de piel pueden confundirse con erisipela porcina. A. suis y A. equuli son patógenos oportunistas emergentes en la industria porcina y ambos tienen potenciales consecuencias en salud pública, principalmente en aquellas personas que manipulan productos cárneos. El objetivo de esta publicación es presentar una revisión bibliográfica sobre el rol de A. suis y A. equuli en la patogénesis de nefritis en cerdos.

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Porcine mannan-binding lectin A binds to Actinobacillus suis and Haemophilus parasuis

Cited by 30 publications

References 53 publications

Association study of genetic variants at single nucleotide polymorphism rs109231409 of mannose-binding lectins 1 gene with mastitis susceptibility in Vrindavani crossbred cattle

Association study of genetic variants at single nucleotide polymorphism rs109231409 of mannose-binding lectins 1 gene with mastitis susceptibility in Vrindavani crossbred cattle

Koyunlarda Mannoz Bağlayan Lektin (MBL) Polimorfizmi ve Mycoplasma ovipneumoniae Enfeksiyonu Sonrasında Serum MBL Protein Seviyeleri İle İlişkisi

Actinobacillus suis and Actinobacillus equuli, emergent pathogens of septic embolic nephritis, a new challenge for the swine industry

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