Porcine Dermal Collagen: A New Option for Soft-Tissue Reconstruction of the Lip

Benito-Ruiz, Jesús; Guisantes, Eva; Serra-Renom, José María

doi:10.1097/01.prs.0000220001.83772.36

Cited by 14 publications

(4 citation statements)

References 4 publications

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“…Permacol™ surgical implant is commercialized for soft tissue reconstruction and repair. It has been used in a variety of surgical fields since 199836, 37 and it has been used successfully for the reconstruction of human soft tissue and as a supporting tissue in numerous gynecologic, urologic, and general surgical procedures involving the treatment of abdominal wall defects,36, 38–41 hernia repair,42–44 soft tissue reconstruction,2, 45 stress incontinence, and vaginal and rectal prolapse 46. Nevertheless, the host response (human) is not frequently analyzed, most certainly for ethical reasons.…”

Section: Discussionmentioning

confidence: 99%

Effect of crosslinking on the performance of a collagen‐derived biomaterial as an implant for soft tissue repair: A rodent model

Brás

Proffitt²,

Bloor³

et al. 2010

J Biomed Mater Res

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One of the main problems in healthcare is the loss of tissues resulting from diseases, post-surgery complications or trauma. As a result there is a need for biomaterials designed to promote tissue regeneration and improve wound healing. This study assessed the effect of crosslinking of a porcine dermal collagen matrix with regard to strength of implant/host tissue integration, implant biocompatibility and general healing in a rodent model. Permacol™, a crosslinked acellular collagenous biomaterial was compared with its noncrosslinked equivalent at 3, 6, and 12 months postsubcutaneous implantation. Both matrices were well tolerated and showed no evidence of inflammation or adverse responses either in the host tissue or implants. Progressive integration of the implants with the surrounding tissue was observed. Cellular response was similar for both collagenous matrices although, at 3 and 6 months, noncrosslinked implants showed a significantly higher level of cellular penetration than crosslinked implants. However, at 12 months crosslinked implants showed significantly higher levels of cellular density, neo-vascularisation and integration with host tissue. Additionally, at long term, noncrosslinked implants lost volume suggesting some absorption. The crosslinking process does not seem to be detrimental to cellular response and biocompatibility.

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Section: Discussionmentioning

confidence: 99%

Effect of crosslinking on the performance of a collagen‐derived biomaterial as an implant for soft tissue repair: A rodent model

Brás

Proffitt²,

Bloor³

et al. 2010

J Biomed Mater Res

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“…Collagen matrices have been employed effectively across a wide range of surgical specialties for the reconstruction of connective tissue. Abdominal wall defects, pelvic floor dysfunction and facial reconstruction have all had successful employment of collagen mesh.…”

Section: Discussionmentioning

confidence: 99%

Repair of traumatic muscle herniation with acellular porcine collagen matrix

2013

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“…To date, its use has been described in a variety of surgical procedures, including abdominal wall repair, tracheoesophageal fistula reconstruction and reconstruction after separation of conjoined twins. Its use has also been described in facial reconstruction, including in augmentation rhinoplasty, lip reconstruction, forehead contour correction and nasolabial fold reconstruction . To date, its use has not been reported in reconstruction of the pinna.…”

mentioning

confidence: 99%