Porcine‐Derived Biomaterials in Tissue Engineering and Reconstructive Surgery: Considerations and Alternatives in Muslim Patients

Abstract

During the last three decades, tissue engineering and reconstructive surgery have become standard therapeutic options in the world of medicine. Several biomaterials, either alone or in combination with cultured cellular products, have been introduced to compensate for the scarcity of autologous donor tissue or to improve healing in a variety of surgical specialties, for example, abdominal/visceral surgery, plastic surgery, and cardiovascular surgery. Many of these biomaterials are of porcine origin.It is well known that Islam has prohibited the consumption of porcine or any of its products. With Muslims accounting for 23% (1.6 billion) of the global population, a thorough review of the implications of porcine-derived tissue-engineered products in surgery seems necessary. In life-threatening conditions as well as severe diseases, the use of porcine-derived products is permissible if similar non-porcine-derived materials are not available. In this case, the use of porcine-derived products represents a necessity and is allowed. Therefore, this distinction between sole need and necessity has great importance not only for the medical community but also for researchers in biotechnology and industry who may consider alternatives to porcine-derived materials. KEYWORDSMuslim patients, porcine-derived biomaterials, regenerative surgery 2001). Therefore, these materials have been selected carefully to

In Vivo Biocompatibility Analysis of a Novel Barrier Membrane Based on Bovine Dermis-Derived Collagen for Guided Bone Regeneration (GBR)

“…Although porcine-derived collagen membranes have become the new gold standard as resorbable barrier membranes for GBR, recent results have shown that bovine-sourced materials seem to provide a special integration pattern including a so-called "secondary porosity" in combination with a transmembraneous vascularization pattern that can potentially serve as a further basis to support the restitutio ad integrum of jawbone defects [39,40]. Thus, such a barrier membrane may bioactively contribute to the osseous regeneration via generation of a healing-supportive microenvironment during the GBR proce- At day 90 post implantationem, comparable mean vessel diameter values were detected in all study groups (Figure 18 and Table 11).…”

Assessment of inflammatory suppression and fibroblast infiltration in tissue remodelling by supercritical CO2 acellular dermal matrix (scADM) utilizing Sprague Dawley models

“…ADM is fabricated by the removal of cellular components from the dermal compartment, exhibiting natural bioactive signals, suitable compatibility with living tissues, and mechanical characteristics, which thus functions as a structural scaffold consisting of extracellular matrix components ( Nikolova and Chavali, 2019 ; Dussoyer et al, 2020 ). Based on its derivation, current ADMs that exist commercially are categorized into human-derived ADMs, porcine-derived ADMs, and bovine-derived ADMs ( Almarzouqi et al, 2018 ; Pires et al, 2022 ). In this study, we investigated the histological and biochemical characteristics of the novel human-derived ADMs (scADM) produced by DOF company in vivo .…”

Evaluation of Eruption of Permanent Teeth in Beagle Dog Extraction Sites Filled with Carbonate Apatite

“…Because most collagen is derived from animals such as bovines and pigs, its use is expected to be difficult for religious reasons. For example, it is well known that Islam, which accounts for 23% of the world's population (1.6 billion people), prohibits the consumption of pork and its products [32]. CA bone graft material does not contain collagen complexes and is therefore considered to be a viable bone graft material for use in many countries.…”