Porcine circovirus type 3 in the UK

Collins, P. J.; McKillen, John; Allan, Gordon

doi:10.1136/vr.j5505

Cited by 45 publications

(34 citation statements)

References 6 publications

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“…It was initially found in 2016 in tissues of swine affected by porcine dermatitis and nephropathy syndrome (PDNS), reproductive failure, and cardiac and multisystemic inflammation (Palinski et al, 2017;Phan et al, 2016) in the USA. Subsequently, other reports from Europe (Collins, McKillen, & Allan, 2017;Faccini et al, 2017;Franzo, Legnardi, Hjulsager et al, 2018;Stadejek, Wo zniak, Miłek, & Biernacka, 2017), Asia Ku et al, 2017;Kwon, Yoo, Park, & Lyoo, 2017;Shen et al, 2017;Zhai et al, 2017;Zheng et al, 2017) and South America (Tochetto et al, 2017) described the presence of PCV-3 genome in tissue samples or sera from pigs with different clinical presentations as well as in healthy animals.…”

Section: Introductionmentioning

confidence: 99%

Retrospective detection of Porcine circovirus 3 (PCV-3) in pig serum samples from Spain

Klaumann

Franzo

Sohrmann

et al. 2018

Transbound Emerg Dis

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SummaryPorcine circovirus 3 (PCV-3) is an emerging circovirus species that has recently been reported in different countries around the world, suggesting a widespread circulation. In this study, sera samples originating from 654 pigs of different production phases and clinical/pathological conditions, submitted for diagnostic purposes between 1996 and 2017, were randomly selected. Detection of PCV-3 genome in such samples was attempted with a previously described PCR method, and the par- Although the information obtained was limited, PCV-3 did not appear to be linked to any specific pathological condition or age group. K E Y W O R D Spolymerase chain reaction, Porcine circovirus 3, retrospective, sequencing, Spain

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Section: Introductionmentioning

confidence: 99%

Retrospective detection of Porcine circovirus 3 (PCV-3) in pig serum samples from Spain

Klaumann

Franzo

Sohrmann

et al. 2018

Transbound Emerg Dis

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“…Like PCV2, there are two major open reading frames (ORFs) in the genome of PCV3: ORF1 encodes proteins involved in viral replication (Rep) and ORF2 encodes a major structural protein, the capsid protein (Cap) 25. PCV3 sequences were detected widely in the USA,21 China,26, 27, 28 Brazil,29 Thailand,30 Korea,23 and many European countries,22, 31, 32, 33, 34 including Poland, Italy, Spain, Denmark, Germany, the UK among others. The PCV3 that was first identified in the USA was more closely related to canine circovirus although with weak bootstrap support 21.…”

Section: Introductionmentioning

confidence: 99%

Origin, Genetic Diversity, and Evolutionary Dynamics of Novel Porcine Circovirus 3

et al. 2018

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Porcine circovirus 3 (PCV3) is a novel virus associated with acute PDNS (porcine dermatitis and nephropathy syndrome)‐like clinical signs identified by metagenomic sequencing from swine. Its high occurrence may pose a potential threat to the swine industry worldwide. The processes resulting in the emergence and spread of PCV3 remain poorly understood. Herein, the possible origin, genotypes, and evolutionary dynamics of PCV3 based on available genomic sequences are determined. The closest ancestor of PCV3 is found to be within the clade 1 bat CVs. Using different phylogenetic methods, two major genotypes are identified, PCV3a and PCV3b. It is found that the effective population size of PCV3 increased rapidly during late 2013 to early 2014 and this is associated with the diversification of PCV3a and PCV3b. A relatively high effective reproductive number (Re) value and higher evolutionary rate were found compared to other single‐stranded DNA viruses, and positive selection on codons 122 and 320 (24 of ORF2) is identified. It is hypothesized that this, together with the prediction of a potential change of an antigenic epitope at position 320, might have allowed PCV3 to escape from the host immune response. Overall, this study has important implications for understanding the ongoing PCV3 cases worldwide and will guide future efforts to develop effective preventive and control measures.

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“…Almost concomitantly, another research group in the United States found PCV3 in tissues of sows with PDNS, as well as in mummified foetuses aborted from such sows (Palinski et al, 2017). Subsequently, PCV3 was reported in China, Poland, South Korea, Brazil, Italy and the UK (Faccini et al, 2017;Fu et al, 2017;Kwon, Yoo, Park, & Lyoo, 2017;Stadejek, Wozniak, Milek, & Biernacka, 2017;Tochetto et al, 2017;Ku et al, 2017;Collins, McKillen, & Allan, 2017). The PCV3 genome comprises a circular single-stranded DNA of 2,000 bp in length, consisting of two major open reading frames (ORFs).…”

Section: Introductionmentioning

confidence: 99%

Detection and phylogenetic analysis of porcine circovirus type 3 in central China

Zhang

Zhao

et al. 2018

Transbound Emerg Dis

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Porcine circovirus type 3 (PCV3) is the pathogen responsible for a new infectious disease that was first reported in 2016 in the United States. To further investigate the epidemic profile and genetic diversity of the virus, one hundred and seventy clinical samples (110 tissue samples and 60 serum samples) were collected from 41 different pig farms in 14 cities in central China, and a SYBR Green I-based quantitative real-time PCR method was developed to detect PCV3. The partial cap genes of four field strains from four different farms were sequenced and analysed. The results showed the detection limit was 2.19 × 10 genome copies/μl. Fifty-three of 170 samples were detected as positive for PCV3, giving a PCV3-positive rate of 31.18%, with 48.78% (20/41) of pig farms harbouring PCV3, which varied from 20% to 42.86% between 2013 and 2017. PCV3 could be detected in samples from pigs with different clinical presentations, and the PCV3-positive rates varied for these different clinical presentations. The partial capsid genes of four PCV3 strains (designated YZ, LY-03, NY and SP) shared 96.3%-99.4% nucleotide identity with those available in GenBank. Phylogenetic analysis based on the capsid gene of 32 PCV3 strains showed that the four PCV3 strains in this study were clustered with the China/GD2016 and South Korea Ku-1606 strains. The results of this study will aid our understanding of the molecular epidemiology of PCV3.

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Porcine circovirus type 3 in the UK

Abstract: A novel porcine circovirus distantly related to known circoviruses is associated with porcine dermatitis and nephropathy syndrome and reproductive failure.

Cited by 45 publications

References 6 publications

Retrospective detection of Porcine circovirus 3 (PCV-3) in pig serum samples from Spain

Retrospective detection of Porcine circovirus 3 (PCV-3) in pig serum samples from Spain

Origin, Genetic Diversity, and Evolutionary Dynamics of Novel Porcine Circovirus 3

Detection and phylogenetic analysis of porcine circovirus type 3 in central China

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