Porcine carotid artery replacement with biodegradable electrospun poly-e-caprolactone vascular prosthesis

Abstract

Biodegradable, electrospun PCL grafts showed good surgical and mechanical properties, no aneurysm formation, and similar short-term patency compared with ePTFE grafts. Rapid endothelialization and cell ingrowth confirms favorable PCL graft-recipient biological interaction. Despite good early results, long-term follow-up is required before clinical application.

Enzyme-functionalized vascular grafts catalyze in-situ release of nitric oxide from exogenous NO prodrug

“…However, in control group, the surface is red due to the infiltration of red cells (Fig. 5B) [37]. Similar differences were also observed at day 14, and some microthrombi were evident on the surface of control group (arrow indicated).…”

Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts

“…It requires cellular ingrowth from native tissues along with material degradation, then eventually forms a functional vascular replacement. The SDVGs prepared from biodegradable synthetic polymers, such as polylactide [3,4], poly(glycerol sebacate) [5], polycaprolactone [6,7] and polyurethane [8], have been investigated for this purpose. However, the implanted material would induce acute thrombosis and intimal hyperplasia (IH, smooth muscle cell over-proliferation), which are two major barriers to the biodegradable SDVGs.…”

Vascular Grafting Strategies in Coronary Intervention

“…An increase in neoendothelialization from 58 to 86% was also observed in the PCL grafts. Despite the increase in endothelialization, neointima, and thrombus formation were not improved with the PCL electrospun vascular grafts (Mrówczyński et al, 2014). In a long-term followup study, the authors compared the patency of the bilayered PCL vascular graft against the ePTFE prosthesis in a Sprague-Dawley rat aorta replacement study.…”