Porcine Acute Phase Protein Concentrations in Different Diseases in Field Conditions

Abstract

Five acute phase proteins (APPs) [C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), pig-MAP and albumin] were measured in pigs with naturally occurring infections by porcine reproductive and respiratory syndrome virus (PRRSV), Aujeszky's disease virus (ADV), porcine circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae, and in animals with tail and ear bites, arthritis and other acute inflammatory processes. Healthy specific pathogen-free (SPF) pigs were used as controls. In PRRSV-infected pigs, all APPs with the exception of pig-MAP exhibited significant changes compared with controls. In animals affected with ADV only Hp presented changes of statistical significance, whereas pigs with PCV2 showed marked modifications in all APPs tested. Animals affected with Mycoplasmosis showed concentrations of all positive APPs significantly above levels obtained in SPF pigs, though albumin concentrations did not differ from controls. Finally, all APPs studied showed substantial changes in pigs with acute inflammation. The results indicated that an acute phase response was developed in the different diseases studied, this response being higher in animals with clinical signs and concurrent bacterial processes. Haptoglobin would be the APP that better reflects pathological states; however, to get more complete and valuable information it might be advisable to perform APPs profiles including another APP, such as CRP or SAA.

Haptoglobin serum concentration is a suitable biomarker to assess the efficacy of a feed additive in pigs

“…This result agrees with those obtained in pigs clinically affected after experimental infection with Aujeszky virus and Aujeszky field cases, where a more sensitive response of haptoglobin changes is observed compared to Pig-MAP (Parra et al, 2006;Carpintero et al, 2007), although, in our case, the magnitude of the increase is lower than the described for these authors. These results are foreseeable because the virulence of a MLV is always lower than the wild virus (Shams, 2005).…”

“…-E-mail: anna.bassols@uab.cat post-weaning multisystemic wasting syndrome and porcine respiratory disease complex (Segales et al, 2004;Parra et al, 2006).…”

Pig peripheral blood mononuclear leucocyte subsets are heritable and genetically correlated with performance

“…Our definition of health status is based on the presence of major swine diseases that consistently affect both animal welfare and performance (Poppe et al, 1998;Pallarés et al, 2000;Regula et al, 2000;Segalé s et al, 2004), although the use of APP as potential indicators of health status is currently under investigation (Parra et al, 2006;Tecles et al, 2007). In general, the traits we measured were consistent between high and lower health status farms, with two notable exceptions, levels of WBC and CD8a 1 cells.…”

The Effects of Acute Exposure to Deoxynivalenol on Some Inflammatory Parameters in Miniature Pigs

“…Acutephase proteins are suggested to be useful markers for the monitoring of some diseases, and Hp is the most sensitive acute-phase protein to detect pathological states in pigs [18]. In the present study SAA was found to be a good indicator in pigs acutely exposed to DON.…”