Populations at high risk of cervical cancer in Guangxi Province: Findings from two screening projects in a minority area of South China

Abstract

Objective To analyse the positive rates of low-grade (LSIL) and high-grade (HSIL) squamous intraepithelial lesions, and cervical cancer (CC), and identify groups at high risk for CC in Guangxi. Setting CC screening options in Guangxi, which is the only minority autonomous area in South China, include the National Cervical Cancer Screening Project (NCCSP) and physical examination (PE). Methods This study was based on PE and NCCSP sample data obtained from 2012 to 2019. We calculated the positive rates of LSIL, HSIL, and CC; analysed the adjusted odds ratio (aOR) and 95% confidence intervals (CI) of the variables in multivariate logistic regression; and subsequently identified groups at high risk for CC. Results The positive rates of LSIL, HSIL, and CC for the total of 873,880 samples were 1.89%, 0.60%, and 0.03%, respectively. Females over 64 years of age (vs. 50–64; aOR = 2.05; 95% CI, 1.71–2.46; P < 0.001) and those from urban (vs. rural; aOR = 1.66; 95% CI, 1.57–1.76; P < 0.001), minority (vs. non-minority; aOR = 1.24; 95% CI, 1.13–1.35; P < 0.001), and coastal (vs. inland; aOR = 1.15; 95% CI, 1.06–1.25; P = 0.001) areas were associated with a high risk of HSIL. Females over 64 (vs. 50–64; aOR = 4.37; 95% CI, 2.88–6.63; P < 0.001) and those from urban (vs. rural; aOR = 3.05; 95% CI, 2.36–3.95; P < 0.001) areas were significantly associated with a high risk of CC. Conclusion Females from urban areas in Guangxi are at high risk for CC. Public health strategies should focus on high-risk populations.

A population-based cross-sectional study on the situation of cervical cancer screening in Liaoning, China

“…As a part of this health care reform, China’s government launched a major public health service project, namely, the National Cervical Cancer Screening Program (NCCSP)[ 7 ]. The NCCSP began in 2009, and was jointly promoted by the National Health Administration and the All-China Women’s Federation to carry out free screening for women aged 30–59 (adjusted to 35–64 in 2012)[ 8 ]. The traditional Pap’s method of cervical cytology was used for the initial screening, and the subjects with positive results continued to undergo colposcopy and pathological examination.…”

“…The traditional Pap’s method of cervical cytology was used for the initial screening, and the subjects with positive results continued to undergo colposcopy and pathological examination. The local maternal and child health and family planning service centers are specifically responsible for organizing the implementation[ 8 ]. Generally, the nurse samples the vaginal secretion, the pathologist judges the cytological results, and the colposcopy is performed by the doctor.…”