Population studies and the Old Order Amish

Cross, Harold E.

doi:10.1038/262017a0

Cited by 38 publications

(20 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In one Amish sub-faction, the average relatedness of married couples is a little closer than second cousins, which is actually more distant than had all members been randomly paired (Hurd 1985); in a large Pennsylvania settlement, the inbreeding level nearly equates to second cousins (Dorsten, Hotchkiss, and King 1999;Khoury, et al 1987a). Further, because Amish rarely marry across sub-affiliation lines (Hurd 1997) or across settlements, and because they usually stay in the community in which they were born (Cross and McKusick 1970;Donnermeyer and Cooksey 2004), inbreeding is intensified, each major settlement representing a genetic sub-isolate (Cross 1976). High levels of relatedness are positively associated with farming as an occupation, younger age at marriage, higher number of siblings, and having a common last name (Khoury, Cohen, et al 1987a).…”

Section: Fertilitymentioning

confidence: 99%

“…Amish have been useful for demographic and genetic studies because they are highly independent of larger society, are endogamous and therefore have a closed gene pool, keep meticulous genealogies, are relatively homogenous in socio-economic indicators, have very low rates of infidelity and divorce, possess relative socio-economic consistency across the population, create permanent conjugal institutions in which nearly all children are born, and have comparatively large families (Cross 1976;Cross & McKusick 1970;McKusick, et al 1964). Amish population growth results from high birth rates, low death rates, and high retention rates (Donnermeyer & Cooksey 2004;Smith 1961), albeit not a high non-Amish conversion rate.…”

Section: Basic Demographic Dynamicsmentioning

confidence: 99%

See 1 more Smart Citation

Reviving the Demographic Study of the Amish

Colyer¹,

Anderson²,

Stein³

et al. 2017

Journal of Amish and Plain Anabaptist Studies

View full text Add to dashboard Cite

The Amish exhibit distinctive demographic patterns, notably high fertility. While scholars have studied Amish population dynamics for more than a half century, recent research in this area is limited. We believe the time is ripe to reverse this trend. This article reviews data collection methods, points to a variety of accessible sources of new data, presents some preliminary results from the analysis of one such source (the McKune dataset for Holmes County, Ohio), introduces the research agenda and work of the newly formed Amish Population Research Group, and reviews past demographic findings to situate our agenda. An invitation is extended to demographers, social scientists, health researchers, and others to enter into collaborations with APRG.

show abstract

Section: Fertilitymentioning

confidence: 99%

Section: Basic Demographic Dynamicsmentioning

confidence: 99%

Reviving the Demographic Study of the Amish

Colyer¹,

Anderson²,

Stein³

et al. 2017

Journal of Amish and Plain Anabaptist Studies

View full text Add to dashboard Cite

show abstract

“…Although variation in aspirin response is highly heritable, few genetic variants had been associated with individual variation in aspirin response. This aspirin response study was performed with subjects from the Old Order Amish population – a highly homogeneous population (Cross, 1976). Specifically, serum from 165 HAPI Heart Study participants who had been exposed to aspirin was assayed using an untargeted GC-MS platform and the identified metabolites were then associated with response to aspirin which was measured using ex vivo assays of collagen-stimulated platelet aggregation.…”

Section: Pharmacometabolomics-informed Pharmacogenomicsmentioning

confidence: 99%

Pharmacometabolomics informs pharmacogenomics

2016

View full text Add to dashboard Cite

Introduction The initial decades of the 21st century have witnessed striking technical advances that have made it possible to detect, identify and quantitatively measure large numbers of plasma or tissue metabolites. In parallel, similar advances have taken place in our ability to sequence DNA and RNA. Those advances have moved us beyond studies of single metabolites and single genetic polymorphisms to the study of hundreds or thousands of metabolites and millions of genomic variants in a single cell or subject. It is now possible to merge and integrate large data sets generated by the use of different “-omics” techniques to increase our understanding of the molecular basis for variation in disease risk and/or drug response phenotypes. Objectives This “Brief Review” will outline some of the challenges and opportunities associated with studies in which metabolomic data have been merged with genomics in an attempt to gain novel insight into mechanisms associated with variation in drug response phenotypes, with an emphasis on the application of a pharmacometabolomics-informed pharmacogenomic research strategy and with selected examples of the application of that strategy. Methods Studies that used pharmacometabolomics to inform and guide pharmacogenomics were reviewed. Clinical studies that were used as the basis for pharmacometabolomics-informed pharmacogenomic studies, published in five independent manuscripts, are described briefly. Results Within these five manuscripts, both pharmacokinetic and pharmacodynamic metabolomics approaches were used. Candidate gene and genome-wide approaches that were used in concert with these metabolomic data identified novel metabolite-gene relationships that were associated with drug response phenotypes in these pharmacometabolomics-informed pharmacogenomics studies. Conclusion This “Brief Review” outlines the emerging discipline of pharmacometabolomics-informed pharmacogenomics in which metabolic profiles are associated with both clinical phenotypes and genetic variants to identify novel genetic variants associated with drug response phenotypes based on metabolic profiles.

show abstract

“…Hostetler has further developed this concept, contending that a folk society can be characterized as an isolated, homogeneous community in which oral and face-to-face communications are highly valued [12]. Using this concept, Hostetler and others [12][13][14][15] claim that Amish society is a folk society in the sense that it values slow changes and traditional ways of living. These writings discuss how the Amish have responded to changes in the broader community while adhering to their traditions.…”

Section: Tomomi Nakamentioning

confidence: 99%

Finding Cultural Lessons in an Unfamiliar Society: An Analysis of Japanese Books about the Amish

Naka¹

2017

IJCH

View full text Add to dashboard Cite

Abstract-This article examines the ways in which Amish life and society are discussed in Japanese books. The Amish are a religious and cultural minority group living mainly in the United States and Canada. Most people in Japan have little or no historical and cultural ties to them. However, many Japanese books have been written about the Amish. An examination of these books indicates that in comparison with English scholarly books about the Amish, Japanese books discuss this group's cultural and social context more explicitly. This article argues that through such discussions, Japanese books not only explain that Amish society and community life are different from that of Japan's, but also offer useful insights for Japanese readers.

show abstract

Population studies and the Old Order Amish

Cited by 38 publications

References 4 publications

Reviving the Demographic Study of the Amish

Reviving the Demographic Study of the Amish

Pharmacometabolomics informs pharmacogenomics

Finding Cultural Lessons in an Unfamiliar Society: An Analysis of Japanese Books about the Amish

Contact Info

Product

Resources

About