We describe two cases of human infections caused by Staphylococcus aureus clonal complex (CC) 75, also called Staphylococcus argenteus, harbouring the Panton-Valentine leucocidin (PVL). These two sporadic cases were community-acquired, and identified in France in 2014. Both had an epidemiological link with Mayotte, an overseas department of France located in the Indian Ocean off the south-eastern African coast. This report illustrates that, contrary to previous descriptions, S. argenteus can acquire important virulence factors and be responsible for severe infections.In 2014, two cases of human infections caused by Staphylococcus aureus isolates belonging to clonal complex (CC) 75 lineage, also called Staphylococcus argenteus, harbouring the Panton-Valentine leucocidin (PVL) occurred in France. The two cases were sporadic and community-acquired, and had an epidemiological link with Mayotte, a French archipelago in the Indian Ocean. The two strains affecting the respective cases were both isolated from blood culture.