Population pharmacokinetics/pharmacodynamics modelling of enrofloxacin for the three major trout pathogens Aeromonas salmonicida, Flavobacterium psychrophilum and Yersinia ruckeri

Viel, Alexis; Rostang, Antoine; Morvan, Marie-Line; Fournel, Catherine; Daniel, P.; Thorin, Chantal; Baron, Sandrine; Sandérs, Pascal; Calvez, Ségolène

doi:10.1016/j.aquaculture.2021.737119

Cited by 14 publications

(14 citation statements)

References 66 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ciprofloxacin with low concentrations has also been reported in the other fish species (11,13,18,28,29), and it was not detected in Takifugu flavidus (30), rainbow trout (17,19), European cuttlefish (31), Atlantic salmon (32), and crucian carp (33). These results indicated a low metabolization into ciprofloxacin for enrofloxacin in fish species.…”

Section: Discussionmentioning

confidence: 99%

“…Enrofloxacin serves as a last-line treatment in aquaculture, and it effectively treats the bacterial infections caused by F. columnare (6), A. hydrophila (9), and A. sobria (10). The plasma pharmacokinetics of enrofloxacin has been reported in some fish species, such as crucian carp (11,12), large yellow croaker (13), tilapia (14), snakehead fish (15), brown turbot (16), and salmonids (17). In addition to those pharmacokinetics studies, the tissue distribution of enrofloxacin has also been reported in aquaculture species, including northern snakeheads (18), rainbow trout (19,20), grass carp (21), largemouth bass (22), and pacu (23).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)

et al. 2022

View full text Add to dashboard Cite

The pharmacokinetics and tissue distribution of enrofloxacin were determined in Yellow River carp (Cyprinus carpio haematopterus) reared at 20°C after single oral administration of enrofloxacin at 10 mg·kg−1 body weight (BW). Plasma, bile, and different tissue samples, including liver, kidney, gill, gut, and skin-muscle, were collected at predetermined times points. An HPLC method was developed to simultaneously determine the concentrations of enrofloxacin and its metabolite, ciprofloxacin. However, ciprofloxacin was only detectable in some liver samples with trace levels. Then the average enrofloxacin concentrations vs. time data were subjected to a non-compartmental analysis using WinNonLin 5.2 software. Multiple peaking profiles were observed in all enrofloxacin concentration-time curves. The peak concentration (Cmax) values were observed as 0.79, 1.01, 2.09, 2.85, 4.34, 10.78, and 13.07 μg·ml−1 (or g−1) in plasma, skin-muscle, gill, kidney, liver, bile, and gut, respectively, and the corresponding time to reach peak concentration (Tmax) was 8, 8, 1, 8, 1, 72, and 4 h, respectively. The values of elimination half-life (T1/2λZ) of enrofloxacin in different tissues was in the following order: gill (291.13 h) > liver (222.29 h) > kidney (157.22 h) > plasma (129.44 h) > gut (91.47 h) > skin-muscle (87.77 h) > bile (86.22 h). The present results showed that enrofloxacin had a wide distribution in different tissues, however slow absorption and elimination in Yellow River carp. Additionally, enrofloxacin exhibited large distribution in bile, indicating that bile excretion might be the primary elimination route of enrofloxacin in Yellow River carp. A withdrawal period was calculated as 379.2 °C-day for single oral dosing of enrofloxacin at 10 mg/kg BW. Based on the calculated PK/PD indices of AUC/MIC or Cmax/MIC, the current enrofloxacin dosing regimen might have a positive therapeutic effect on the infection of Flavobacterium columnare, Aeromonas sobria, or Aeromonas hydrophila. However, the depletion study following multiple oral doses should be carried out in Yellow River carp reared at lower temperatures, and the withdrawal period should also be further calculated.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The traditional dose of enrofloxacin in fish is 10 mg/kg, and it has been used at doses between 5 and 80 mg/kg in previous studies [ 17 , 30 , 31 ]. After a single oral administration of enrofloxacin at different doses (10, 20 and 40 mg/kg) in rainbow trout, no biochemical and histopathological changes were observed, except for epithelial hyperplasia in the gill at a dose of 40 mg/kg [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Enrofloxacin showed wide V darea /F ranging from 1.55 to 2.26 L/kg following administration at doses of 10, 20, and 40 mg/kg. Enrofloxacin has a large V d of 2.56 to 5.75 L/kg in fish due to its high lipophilic solubility and low (≤8.8%) plasma protein binding [ 16 , 17 , 30 ]. In this study, according to 10 mg/kg dose, the V darea /F of enrofloxacin in brown trout unimportantly increased by 11.88% at 20 mg/kg dose and decreased by 23.27% at 40 mg/kg dose.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

Üney

Terzi̇

Çorum

et al. 2021

Animals

View full text Add to dashboard Cite

The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non-compartmental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose-normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non-linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96-fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 µg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout.

show abstract

A modified withdrawal time estimation and risk assessment of enrofloxacin in grass carp (Ctenopharyngodon idella) after ad libitum medicated feed based on statistical approaches in natural cultured environments

Xu,

Zhang,

Dong

et al. 2024

Vet Res Commun

View full text Add to dashboard Cite

Population pharmacokinetics/pharmacodynamics modelling of enrofloxacin for the three major trout pathogens Aeromonas salmonicida, Flavobacterium psychrophilum and Yersinia ruckeri

Cited by 14 publications

References 66 publications

Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)

Pharmacokinetics and Tissue Distribution of Enrofloxacin Following Single Oral Administration in Yellow River Carp (Cyprinus carpio haematoperus)

Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)

A modified withdrawal time estimation and risk assessment of enrofloxacin in grass carp (Ctenopharyngodon idella) after ad libitum medicated feed based on statistical approaches in natural cultured environments

Contact Info

Product

Resources

About