Abstract:Esomeprazole is a proton pump inhibitor being investigated for treatment
of preeclampsia. Esomeprazole pharmacokinetics during pregnancy is
unknown. We used data from 10 pregnant patients with preterm
preeclampsia, and 49 non-pregnant individuals to develop a population
pharmacokinetic model of esomeprazole. A two-compartment model described
the data well. In pregnant patients after single dose, clearance was
42.2% (14.9%– 61.6%) lower compared to non-pregnant, most likely due
to downregulation of CYP2C19. In … Show more
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