Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor)

Zordan, Martin; Papich, Mark G.; Pich, Ashley A.; Unger, Katy M; Sánchez, Carlos R.

doi:10.2460/ajvr.77.12.1311

Cited by 16 publications

(5 citation statements)

References 19 publications

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“…These findings contradict popular beliefs that IM dosing is more effective. Interestingly, similar results were observed in lesser flamingos ( Zordan et al, 2016 ). The current oral bioavailability meloxicam in pigeons was higher than those in red-tailedhawks (74%; Lacasse et al, 2013 ), laying hens (70.13%; Shao et al, 2022 ), geese (64.2%; Sartini et al, 2020 ), and great horned owls (62%; Lacasse et al, 2013 ).…”

Section: Discussionsupporting

confidence: 84%

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration

et al. 2023

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Section: Discussionsupporting

confidence: 84%

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration

et al. 2023

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“…This trend was seen in enrofloxacin, marbofloxacin and doxycycline, the only antibiotics in this review that have been studied in ostriches. This trend is also seen in other drugs such as meloxicam and flunixin [ 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ]. Other drugs have also been studied in the common ostrich [ 94 , 109 , 110 , 111 ], but no other studies have been conducted for other exotic avian species and therefore drug half-lives could not be compared.…”

Section: Recommendations For Researchmentioning

confidence: 70%

A Critical Review of the Pharmacokinetics, Pharmacodynamics, and Safety Data of Antibiotics in Avian Species

Soh

Tan

et al. 2022

Antibiotics

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In avian medicine, the use of antibiotic dosing regimens based on species-specific pharmacological studies is ideal. However, due to a lack of such studies, dose extrapolation, which may cause inefficacy and toxicity, is common practice. Multiple searches were performed using the PubMed and Web of Science databases to extract relevant pharmacological studies performed in exotic avian species. The pharmacokinetics (PK), pharmacodynamics (PD), and safety data of the selected antibiotics (enrofloxacin, marbofloxacin, gentamicin, amikacin, ceftiofur, doxycycline, and amoxicillin/clavulanate) from these studies were reviewed. This review aimed to identify trends amenable for safe inter-species dose extrapolation and provide updated findings on dosing regimens that are safe and efficacious for various exotic avian species. We observed that the half-life of antibiotics appears to be shorter in the common ostrich and that amikacin may be amenable to inter-species dose extrapolation as it is safe and shows little inter-species PK and PD variation. Species-specific enrofloxacin dosing regimens that were not listed in the Exotic Animal Formulary (5th ed.) were found for Caribbean flamingos, African penguins, southern crested caracaras, common ostriches, and greater rheas. Specific dosing regimens recommended for psittacine birds (doxycycline 130 mg/kg medicated water) and ratites (PO doxycycline 2–3.5 mg/kg q12 h, PO enrofloxacin 1.5–2.5 mg/kg q12 h and IM enrofloxacin 5 mg/kg q12 h) in the formulary may not be effective in budgerigars and common ostriches, respectively. Apart from the lack of species-specific pharmacological studies, a lack of multiple dose studies was also noted.

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“…14 Conversely, t 1/2 values in finches were longer than those determined for a single intramuscular dose of meloxicam in American flamingos (1.83 h, 1 mg/kg IM), 2 vultures (0.42 h, 2 mg/kg IM), 15 and lesser flamingos (1.93 h, 0.5 mg/kg IM). 18 Unique properties of protein binding and biotransformation likely influence interspecies differences in meloxicam t 1/2 .…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and Safety of Intramuscular Meloxicam in Zebra Finches (Taeniopygia guttata)

Miller

Hill

Carrasco

et al. 2019

j am assoc lab anim sci

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Zebra finches (Taeniopygia guttata) are songbirds that often undergo surgical procedures as part of research into learning and memory; these surgeries include those for intracranial injections and cranial implants. At our institution, birds receive subcutaneous lidocaine (a local anesthetic) and intramuscular buprenorphine (an opioid analgesic) preoperatively, with buprenorphine continued every 12 h postoperatively for 2 to 3 d. More recently, the possibility of substituting meloxicam (a COX2-selective NSAID) for buprenorphine, or adding meloxicam to the existing analgesia regimen for a more multimodal approach, has been suggested. The enhanced pain control derived from using lidocaine, buprenorphine, and meloxicam could be of particular benefit in finch surgeries that are particularly invasive or complicated. However, although meloxicam is the most popular NSAID used in birds, 7 the optimal dose and frequency for zebra finches are unknown. Publications that describe the pharmacokinetics of meloxicam in diverse, nonpasserine avian species (doses ranging from 0.5 to 3.0 mg/kg IM, IV, SC, or PO) 1,2,6,8-10,12-15,18 report a wide range of elimination half-lifes (t 1/2 ). For example, vultures dosed once with 2 mg/ kg meloxicam IM had an elimination t 1/2 of 0.42 h, 15 whereas African grey parrots had a t 1/2 of 35.3 h after a dose of 1 mg/kg IM. 12 Such results have caused numerous authors to emphasize the need for species-specific pharmacokinetic analyses before administering meloxicam to any bird. Additional concerns when giving an NSAID include the potential for renal damage, as reflected in uric acid levels and kidney histology, 16,17 and for gastrointestinal effects; with intramuscular administration, another potential sequela is necrosis at the injection site. As is often the case in laboratory animal medicine, giving meloxicam to zebra finches constitutes an extralabel use.We performed a study using healthy, adult zebra finches that entailed the administration of 1 or 2 mg/kg meloxicam intramuscularly to help elucidate an optimal dosing regimen, as well as to reveal any evidence of toxicity. Pharmacokinetic parameters were assessed after a single dose, whereas biochemical analytes, Hct, and histology were evaluated after multiple doses. Our findings are the first to characterize the use of meloxicam in a passerine species. Materials and MethodsAnimals. Male (n = 46) and female (n = 46) wildtype zebra finches older than 90 d were involved in the study; all the birds were in good health clinically and had adequate body condition scores. Finches were maintained in an AAALAC-accredited facility under a 12:12-h light:dark cycle, with temperatures from 73 to 77 °F (22.8 to 25.0 °C) and ambient humidity set at 30% to 70%. The main diet was a fortified millet-canary grass seed-oat mix (Supreme Fortified Daily Diet: Finch, Kaytee Products, Chilton, WI), to which a high-protein supplement (High Potency Mash, Harrison's Bird Foods, HBD International, Brentwood, TN), moistened and mixed with minced hard-boiled eggs, wa...

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Population pharmacokinetics of a single dose of meloxicam after oral and intramuscular administration to captive lesser flamingos (Phoeniconaias minor)

Cited by 16 publications

References 19 publications

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration

A Critical Review of the Pharmacokinetics, Pharmacodynamics, and Safety Data of Antibiotics in Avian Species

Pharmacokinetics and Safety of Intramuscular Meloxicam in Zebra Finches (Taeniopygia guttata)

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